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Your search keyword '"Hidişoğlu, Enis"' showing total 2 results
Start Over Author "Hidişoğlu, Enis" Topic electroencephalography
2 results on '"Hidişoğlu, Enis"'

1. Alleviation of prilocaine-induced epileptiform activity and cardiotoxicity by thymoquinone.

Author

Akgül, Barış, Aycan, İlker Öngüç, Hidişoğlu, Enis, Afşar, Ebru, Yıldırım, Sendegül, Tanrıöver, Gamze, Coşkunfırat, Nesil, Sanlı, Suat, and Aslan, Mutay

Subjects
PRILOCAINE, CARDIOTOXICITY, CENTRAL nervous system diseases, ELECTRODES, ELECTROENCEPHALOGRAPHY, FEMORAL vein, EPILEPSY, ANIMAL experimentation, RATS, ARTIFICIAL respiration, ELECTROCARDIOGRAPHY, DESCRIPTIVE statistics, LOCAL anesthetics
Abstract

Purpose: This study investigated whether thymoquinone (TQ) could alleviate central nervous system (CNS) and cardiovascular toxicity of prilocaine, a commonly used local anesthetic. Methods: Rats were randomized to the following groups: control, prilocaine treated, TQ treated and prilocaine + TQ treated. Electroencephalography and electrocardiography electrodes were placed and trachea was intubated. Mechanical ventilation was initiated, right femoral artery was cannulated for continuous blood pressure measurements and blood-gas sampling while the left femoral vein was cannulated for prilocaine infusion. Markers of myocardial injury, reactive oxygen/nitrogen species (ROS/RNS) generation and total antioxidant capacity (TAC) were assayed by standard kits. Aquaporin-4 (AQP4), nuclear factor(NF)κB-p65 and -p50 subunit in brain tissue were evaluated by histological scoring. Results: Blood pH and partial oxygen pressure, was significantly decreased after prilocaine infusion. The decrease in blood pH was alleviated in the prilocaine + TQ treated group. Prilocaine produced seizure activity, cardiac arrhythmia and asystole at significantly lower doses compared to prilocaine + TQ treated rats. Thymoquinone administration attenuated levels of myocardial injury induced by prilocaine. Prilocaine treatment caused increased ROS/RNS formation and decreased TAC in heart and brain tissue. Thymoquinone increased heart and brain TAC and decreased ROS/RNS formation in prilocaine treated rats. AQP4, NFκB-p65 and NFκB-p50 expressions were increased in cerebellum, cerebral cortex, choroid plexus and thalamic nucleus in prilocaine treated rats. Thymoquinone, decreased the expression of AQP4, NFκB-p65 and NFκB-p50 in brain tissue in prilocaine + TQ treated rats. Conclusion: Results indicate that TQ could ameliorate prilocaine-induced CNS and cardiovascular toxicity. [ABSTRACT FROM AUTHOR]

Published
2021
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2. Changes of auditory event-related potentials in ovariectomized rats injected with d-galactose: Protective role of rosmarinic acid

Author

Enis Hidisoglu, Yusuf Olgar, Deniz Kantar-Gok, Hakan Er, Alev Duygu Acun, Piraye Yargicoglu, Kantar-Gok, D, Hidisoglu, E, Er, H, Acun, AD, Olgar, Y, Yargicoglu, P, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, and Hidişoğlu, Enis

Subjects
0301 basic medicine, medicine.medical_specialty, Time Factors, Echoic memory, Thiobarbituric acid, Ovariectomy, Lipid peroxidation, Mismatch negativity, Contingent Negative Variation, Context (language use), AERPs, Toxicology, Depsides, Thiobarbituric Acid Reactive Substances, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, D-Galactose, Internal medicine, Reaction Time, medicine, TBARS, Animals, Alzheimer's disease, Rosmarinic acid, Acoustic Stimulation, Aldehydes, Analysis of Variance, Cinnamates, Electroencephalography, Evoked Potentials, Auditory, Female, Galactose, Neuroprotective Agents, Rats, Evoked Potentials, Auditory, General Neuroscience, 030104 developmental biology, Endocrinology, chemistry, Ovariectomized rat, 030217 neurology & neurosurgery
Abstract

Rosmarinic acid (RA), which has multiple bioactive properties, might be a useful agent for protecting central nervous system against age related alterations. In this context, the purpose of the present study was to investigate possible protective effects of RA on mismatch negativity (MMN) component of auditory event-related potentials (AERPs) as an indicator of auditory discrimination and echoic memory in the ovariectomized (OVX) rats injected with D-galactose combined with neurochemical and histological analyses. Ninety female Wistar rats were randomly divided into six groups: sham control (5); RA-treated (R); OVX (O); OVX + RA-treated (OR); OVX+ D-galactose-treated (OD); OVX+ D-galactose + RA treated (ODR). Eight weeks later, MMN responses were recorded using the oddball condition. An amplitude reduction of some components of AERPs was observed due to ovariectomy with or without D-galactose administiration and these reduction patterns were diverse for different electrode locations. MMN amplitudes were significantly lower over temporal and right frontal locations in the o and OD groups versus the S and R groups, which was accompanied by increased thiobarbituric acid reactive substances (TBARS) and hydroxy-2-nonenal (4-HNE) levels. RA treatment significantly increased AERP/MMN amplitudes and lowered the TBARS/4-HNE levels in the OR and ODR groups versus the 0 and OD groups, respectively. Our findings support the potential benefit of RA in the prevention of auditory distortion related to the estrogen deficiency and D-galactose administration at least partly by antioxidant actions. (C) 2017 Elsevier B.V. All rights reserved.

Published
2017
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