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This article discusses a clinical trial that aimed to determine the safety and efficacy of electrochemotherapy with bleomycin as part of the standard neoadjuvant down-staging treatment for patients with locally advanced rectal cancer. The trial involved 16 patients who were randomly assigned to either the intervention group, which received the electrochemotherapy treatment in addition to standard preoperative neoadjuvant therapy, or the control group, which only received the standard treatment. The results showed that electrochemotherapy was a safe and feasible treatment option, with no serious adverse events reported. The study also mentioned that the pending PET/MRI tumour volumetric results could provide valuable data for further investigation of the role of electroporation in the treatment of locally advanced rectal cancer. [Extracted from the article]

This article, published in the journal Endoscopy, discusses the use of endoscopic electroporation as a palliative treatment for colorectal cancer. The study, conducted at Zealand University Hospital in Denmark, focused on patients who were not eligible for surgical resection or refused surgical treatment. The researchers found that electroporation was a safe and effective treatment option, with minimal adverse events. It was particularly successful in controlling symptoms such as bleeding. The study suggests that electroporation has potential as a palliative treatment for colorectal cancer patients who are not candidates for standard treatment. [Extracted from the article]