Search

An electrochemical Reformatsky‐type reaction of bromodifluoroamides with aldehydes/ketones via electron reductive umpolung is reported, leading to the generation of a series of β‐hydroxy‐α,α‐difluoro amides in moderate to good yields. This protocol tolerated a variety of commercially available alkyl ketone, alkyl and aromatic aldehydes, featuring broad substrate scope and good functional group tolerance under transition metal‐free conditions without metal reduction reagents. Control experiment indicated that the reaction proceeded via an electron reductive umpolung pathway. [ABSTRACT FROM AUTHOR]

A tunable electrosynthesis of sulfonyl‐ and bromo‐substituted indolo[2,1‐α]isoquinoline derivatives has been disclosed. In this reaction, a variety of easily available 2‐aryl‐N‐acryloyl indoles can readily react with sulfonyl and/or bromine radicals, which are generated from arylsulfonyl hydrazides and potassium bromide respectively, to furnish the valuable sulfonyl‐ and bromo‐substituted benzindolo‐fused polycyclic compounds in moderate to good yields. Control experiment indicated that the reaction proceeds via a radical cascade cyclization pathway. This protocol features broad substrate scope and good functional group tolerance under transition metal‐free and oxidant‐free conditions. [ABSTRACT FROM AUTHOR]