1. Influence of processing conditions in the manufacture of O/W creams: I. Effect on dispersion grade and rheological characteristics.
- Author
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Realdon N, Perin F, Morpurgo M, and Ragazzi E
- Subjects
- Centrifugation, Drug Industry, Drug Stability, Microscopy, Oils analysis, Oils chemistry, Rheology methods, Surface-Active Agents chemistry, Time Factors, Viscosity, Water chemistry, Chemistry, Pharmaceutical methods, Emulsions chemistry, Fatty Alcohols chemistry, Glycerides chemistry, Stearates chemistry
- Abstract
Two series of O/W creams having the same general formulation were prepared in three different mechanical conditions (F with an hand blender; S with a turbomixer; T with a vacuum turbo emulsor) using two types of surfactants, polyoxyethylene-cetostearyl alcohols and polyglyceryl-3-methylglucose-distearate. By means of microscopic image analysis it was possible to point out the dispersion grade of the oil internal phase increasing with the energy applied under the conditions of manufacture (F < S < T). The level of dispersion influenced significantly on the rheological characteristics of the creams. With polyoxyethylene-cetostearyl alcohols, the viscosity of creams increased as the energy applied in manufacturing increased, with polyglyceryl-3-methylglucose-distearate on the contrary decreased. Moreover, indifferently to the manufacturing conditions, even in the same concentration of surfactant, the creams obtained with the last produced a much greater viscosity. At a parity of manufacturing conditions the differences between the batches of productions were not significant.
- Published
- 2002
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