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This article discusses a study that compares the outcomes of two different treatment strategies for nonsurgical patients with acute calculous cholecystitis (ACC). The first strategy involves the use of percutaneous cholecystostomy (PC) followed by endoscopic ultrasound-guided gallbladder drainage (EUS-GBD), while the second strategy involves standard non-endoscopic management. The study found that patients who underwent EUS-GBD had a significantly lower rate of biliopancreatic events (BPE) and readmissions compared to those who received conservative management. The technical success of EUS-GBD was high, with minimal complications and no increase in morbidity or mortality. However, further research is needed to confirm these findings before incorporating this approach into current management algorithms. [Extracted from the article]