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The experiment was conducted to study the effect of composite plant extracts Piper sarmentosum Roxb. and guava leaf on growth performance and serum indexes of weaned piglets. A total of 200 21-day-old weaned piglets were selected and randomly divided into two groups, with five replicates in each group and 20 piglets in each replicate. Piglets in control group were fed with a basal diet, the piglets in experimental group were fed with the basal diet supplemented with composite plant extracts at 200 mg/kg. The experimental period was 21 d. The results showed that there was no significant difference on growth performance of piglets among the groups（P>0.05）. Compared with control group, the experimental group supplemented with the compound plant extract in the diet significantly decreased the serum cholesterol（CHOL） and low-density lipoprotein cholesterol（LDL-C） content of piglets（P<0.05）, glutathione peroxidase（GSH-Px）activity was significantly increased（P<0.05）, serum content of interleukin-4（IL-4）, interleukin-10（IL-10） and transforming growth factor-β（TGF-β） were significantly increased（P<0.05）, the content of interleukin-1β（IL-1β）,interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） were significantly decreased（P<0.05）, and serum endotoxin（ET-1） content and diamine oxidase（DAO） activity were significantly decreased（P<0.05）. The study indicates that adding compound plant extracts to diet can improve the antioxidant performance and immune function of weaned piglets, and improve the intestinal mucosal barrier function of piglets. [ABSTRACT FROM AUTHOR]