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Your search keyword '"Zhong, Hua"' showing total 1 results
Start Over Author "Zhong, Hua" Topic environmental engineering Region east asia
1 results on '"Zhong, Hua"'

1. Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia.

Author

Shi, Hong, Tan, Si-jie, Zhong, Hua, Hu, Wenwei, Levine, Arnold, Xiao, Chun-jie, Peng, Yi, Qi, Xue-bin, Shou, Wei-hua, Ma, Run-un Z., Li, Yi, Su, Bing, and Lu, Xin

Subjects
*GENETIC polymorphisms, *P53 protein, *STATISTICAL correlation, *LOW temperatures, *ENVIRONMENTAL engineering, *CELLS
Abstract

The tumor suppressor p53 is a master sensor of stress. Two human-specific polymorphisms, p53 codon 72 and MDM2 SNP309, influence the activities of p53. There is a tight association between cold winter temperature and p53 Arg72 and between low UV intensity and MDM2 SNP3O9 GIG in a cohort of 4029 individuals across Eastern Asia that suggests causative selection. Moreover, the two polymorphisms are not coselected. Haplotype-based selection analysis further suggests that this is a striking example of two functional polymorphisms being strongly selected for in human populations in response to environmental stresses. [ABSTRACT FROM AUTHOR]

Published
2009
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