1. Short-Term Effects of Particle Size and Constituents on Blood Pressure in Healthy Young Adults in Guangzhou, China.
- Author
-
Guo PY, He ZZ, Jalaludin B, Knibbs LD, Leskinen A, Roponen M, Komppula M, Jalava P, Hu LW, Chen G, Zeng XW, Yang BY, and Dong GH
- Subjects
- Adult, Cardiovascular Diseases epidemiology, Cardiovascular Diseases etiology, China epidemiology, Female, Follow-Up Studies, Healthy Volunteers, Humans, Male, Morbidity trends, Particle Size, Retrospective Studies, Risk Factors, Time Factors, Young Adult, Air Pollutants analysis, Blood Pressure physiology, Cardiovascular Diseases physiopathology, Environmental Exposure adverse effects, Particulate Matter analysis
- Abstract
Background Although several studies have focused on the associations between particle size and constituents and blood pressure, results have been inconsistent. Methods and Results We conducted a panel study, between December 2017 and January 2018, in 88 healthy university students in Guangzhou, China. Weekly systolic blood pressure and diastolic blood pressure were measured for each participant for 5 consecutive weeks, resulting in a total of 440 visits. Mass concentrations of particles with an aerodynamic diameter of ≤2.5 µm (PM
2.5 ), ≤1.0 µm (PM1.0 ), ≤0.5 µm (PM0.5 ), ≤0.2 µm (PM0.2 ), and number concentrations of airborne particulates of diameter ≤0.1 μm were measured. Linear mixed-effect models were used to estimate the associations between blood pressure and particles and PM2.5 constituents 0 to 48 hours before blood pressure measurement. PM of all the fractions in the 0.2- to 2.5-μm range were positively associated with systolic blood pressure in the first 24 hours, with the percent changes of effect estimates ranging from 3.5% to 8.8% for an interquartile range increment of PM. PM0.2 was also positively associated with diastolic blood pressure, with an increase of 5.9% (95% CI, 1.0%-11.0%) for an interquartile range increment (5.8 μg/m3 ) at lag 0 to 24 hours. For PM2.5 constituents, we found positive associations between chloride and diastolic blood pressure (1.7% [95% CI, 0.1%-3.3%]), and negative associations between vanadium and diastolic blood pressure (-1.6% [95% CI, -3.0% to -0.1%]). Conclusions Both particle size and constituent exposure are significantly associated with blood pressure in the first 24 hours following exposure in healthy Chinese adults.- Published
- 2021
- Full Text
- View/download PDF