1. Neuraminidase inhibitory polyketides from the marine-derived fungus Phoma herbarum.
- Author
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Zhang GF, Han WB, Cui JT, Ng SW, Guo ZK, Tan RX, and Ge HM
- Subjects
- Biological Products chemistry, Enzyme Inhibitors chemistry, Enzyme Inhibitors isolation & purification, Molecular Structure, Polyketides chemistry, Polyketides isolation & purification, Ascomycota chemistry, Biological Products pharmacology, Enzyme Inhibitors pharmacology, Neuraminidase antagonists & inhibitors, Polyketides pharmacology
- Abstract
Two new polyketides, arthropsadiol C (1) and massarilactone H (2), together with six known derivatives (3-8) were isolated from the culture broth of the marine-derived fungus Phoma herbarum. Their structures were elucidated on the basis of spectroscopic methods, including 2D NMR techniques. Compounds 2, 4, 5, and 8 showed moderate neuraminidase inhibitory activity with IC(50) values ranging from 4.15 to 9.16 µM., (© Georg Thieme Verlag KG Stuttgart · New York.)
- Published
- 2012
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