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2 results on '"Guillerm D"'

1. INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE WITH FLUORINATED ANALOGS OF 2′- AND 3′-DEOXY-5′-METHYLTHIOADENOSINE.

Author

Guillerm, D., Guillerm, G., and Witkowski-Vandenplas, C.

Subjects
*ADENOSINES, *HYDROLASES, *MASS spectrometry, *ENZYMES
Abstract

Fluorinated analogs of 2′- and 3′-deoxy-5′-methylthioadenosine 1–4 caused irreversible inactivation of AdoHcy hydrolase. Based on the ESI-Mass spectra analysis of the inactivated enzyme with the fluorinated analog 1 a mechanism of inactivation is proposed. [ABSTRACT FROM AUTHOR]

Published
2001
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2. MECHANISM OF INACTIVATION OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE BY 5′-DEOXY-5′-S-ALLENYLTHIOADENOSINE AND 5′-DEOXY-5′-S-PROPYNYLTHIOADENOSINE.

Author

Guillerm, G., Guillerm, D., and Witkowski-Vandenplas, C.

Subjects
*ADENOSINES, *HYDROLASES, *MASS spectrometry, *ENZYMES
Abstract

5′-Deoxy-5′-S-allenylthioadenosine 1 and 5′-deoxy-5′-S-propnylthioadenosine 2, derived from adenosine, were prepared. 1 and 2 caused irreversible inactivation of AdoHcy hydrolase. ESI mass spectra analysis of the inactivated enzyme demonstrated that 1 and 2 were type II “mechanism-based” inhibitors. [ABSTRACT FROM AUTHOR]

Published
2001
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