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1. Peptide-templated gold nanoparticle nanosensor for simultaneous detection of multiple posttranslational modification enzymes.

Author

Zhang, Dandan, Meng, Ya-ru, and Zhang, Chun-yang

Subjects
*POST-translational modification, *ENZYMES, *PHOSPHOPROTEIN phosphatases, *HISTONE deacetylase, *DETECTION limit
Abstract

We developed a peptide-templated gold nanoparticle (AuNP) nanosensor for simultaneous detection of multiple posttranslational modification (PTM) enzymes with a detection limit of 28 pM for histone deacetylase (HDAC) and 0.8 pM for protein tyrosine phosphatase 1B (PTP1B), and it can be further applied for the screening of PTM enzyme inhibitors and the measurement of PTM enzymes in cancer cells. [ABSTRACT FROM AUTHOR]

Published
2020
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