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2 results on '"Denise Sorasio"'

1. Gender Differences in Sinonasal Cancer Incidence: Data from the Italian Registry

Author

Alessandra Binazzi, Davide di Marzio, Carolina Mensi, Dario Consonni, Lucia Miligi, Sara Piro, Jana Zajacovà, Denise Sorasio, Paolo Galli, Angela Camagni, Roberto Calisti, Stefania Massacesi, Ilaria Cozzi, Anna Balestri, Stefano Murano, Ugo Fedeli, Vera Comiati, Silvia Eccher, Sara Lattanzio, Alessandro Marinaccio, and ReNaTuNS Working Group

Subjects
sinonasal cancer, occupational exposure, gender difference, epidemiological surveillance, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background: Although rare, sinonasal cancers (SNCs) have a high occupational attributable fraction. Methods: We applied gender-based approaches to descriptive analyses, incidence, and patterns of exposures using the Italian National Sinonasal Cancer Registry (ReNaTuNS: Registro Nazionale Tumori Naso-Sinusali). Results: The study included 2851 SNC patients. SNC was diagnosed more often in men (73%) than in women (27%). The most frequent morphology in men was intestinal-type adenocarcinoma (33%), whereas in women, it was squamous cell carcinoma (49%). Nasal cavities were predominant in both genders (50%), ethmoidal sinus in men (24%), and maxillary in women (24%). Incidence rates were 0.76 (per 100,000 person-years) in men and 0.24 in women and increased by age, more evidently in men, peaking over 75 years in both. Occupational exposures to wood and leather dusts were the most frequent (41% for men, 33% for women). Few exposures were extra-occupational or domestic. Unlikely exposure was relevant in women (57%). Conclusions: The surveillance of SNC cases through a registry that allows for the identification of and compensation for this occupational disease is important in Italy, where numerous workers are exposed to carcinogens for SNC, without even being aware. Considering the rarity of the disease, particularly among women, the ReNaTuNS can provide a method to analyze gender differences.

Published
2024
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2. Exposures to IARC Carcinogenic Agents in Work Settings Not Traditionally Associated with Sinonasal Cancer Risk: The Experience of the Italian National Sinonasal Cancer Registry

Author

Alessandra Binazzi, Carolina Mensi, Lucia Miligi, Davide Di Marzio, Jana Zajacova, Paolo Galli, Angela Camagni, Roberto Calisti, Anna Balestri, Stefano Murano, Sara Piro, Angelo d’Errico, Matteo Bonzini, Stefania Massacesi, Denise Sorasio, Alessandro Marinaccio, and on behalf of ReNaTuNS Working group

Subjects
Occupational cancer, Health, Toxicology and Mutagenesis, Population, Context (language use), sinonasal cancer, occupational exposure, occupational cancer, epidemiological surveillance, Article, Environmental health, Occupational Exposure, Settore MED/44 - Medicina del Lavoro, Medicine, Humans, Registries, education, education.field_of_study, business.industry, Epidemiological surveillance, Occupational exposure, Sinonasal cancer, Carcinogens, Dust, Occupational Diseases, Paranasal Sinus Neoplasms, Public Health, Environmental and Occupational Health, medicine.disease, Work (electrical), Work history, business
Abstract

The aim of this study is to highlight tasks and jobs not commonly considered at high risk for sinonasal cancer (SNC) identified by Regional Operating Centers currently active in the Italian National Sinonasal Cancer Registry (ReNaTuNS), which retrieve occupational histories through a standardized questionnaire. Data on exposures to IARC carcinogenic agents in work settings unknown to be associated with SNC risk were collected and analyzed. Out of 2,208 SNC cases recorded in the ReNaTuNS database, 216 cases and their worked exposure periods were analyzed. Unsuspected jobs with exposure to wood dust include construction-related tasks, production of resins, agriculture and livestock jobs (straw and sawdust), and heel factory work (cork dust). Other examples are hairdressers, bakers (formaldehyde), dressmakers, technical assistants, wool and artificial fiber spinners, and upholsterers (textile dusts). Moreover, settings with coexposure to different agents (e.g., wood with leather dusts and chromium–nickel compounds) were recognized. The study describes jobs where the existence of carcinogenic agents associated with SNC risk is unexpected or not resulting among primary materials employed. The systematic epidemiological surveillance of all epithelial SNC cases with a detailed collection of their work history, as performed by a dedicated population registry, is essential for detecting all potential occupational cases and should be considered in the context of forensic medicine and the compensation process.

Published
2021

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