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4 results on '"Giraldi, Luca"'

1. Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis.

Author

Tasoulas, Jason, Farquhar, Douglas R, Sheth, Siddharth, Hackman, Trevor, Yarbrough, Wendell G, Agala, Chris B, Koric, Alzina, Giraldi, Luca, Fabianova, Eleonora, Lissowska, Jolanta, Świątkowska, Beata, Vilensky, Marta, Wünsch-Filho, Victor, Carvalho, Marcos Brasilino de, López, Rossana Verónica Mendoza, Holcátová, Ivana, Serraino, Diego, Polesel, Jerry, Canova, Cristina, and Richiardi, Lorenzo

Subjects
HEAD & neck cancer, EPIDEMIOLOGY of cancer, OVERALL survival, ORAL health, CONSORTIA, CANCER patients
Abstract

Background Poor oral health has been identified as a prognostic factor potentially affecting the survival of patients with head and neck squamous cell carcinoma. However, evidence to date supporting this association has emanated from studies based on single cohorts with small-to-modest sample sizes. Methods Pooled analysis of 2449 head and neck squamous cell carcinoma participants from 4 studies of the International Head and Neck Cancer Epidemiology Consortium included data on periodontal disease, tooth brushing frequency, mouthwash use, numbers of natural teeth, and dental visits over the 10 years prior to diagnosis. Multivariable generalized linear regression models were used and adjusted for age, sex, race, geographic region, tumor site, tumor-node-metastasis stage, treatment modality, education, and smoking to estimate risk ratios (RR) of associations between measures of oral health and overall survival. Results Remaining natural teeth (10-19 teeth: RR = 0.81, 95% confidence interval [CI] = 0.69 to 0.95; ≥20 teeth: RR = 0.88, 95% CI = 0.78 to 0.99) and frequent dental visits (>5 visits: RR = 0.77, 95% CI = 0.66 to 0.91) were associated with better overall survival. The inverse association with natural teeth was most pronounced among patients with hypopharyngeal and/or laryngeal, and not otherwise specified head and neck squamous cell carcinoma. The association with dental visits was most pronounced among patients with oropharyngeal head and neck squamous cell carcinoma. Patient-reported gingival bleeding, tooth brushing, and report of ever use of mouthwash were not associated with overall survival. Conclusions Good oral health as defined by maintenance of the natural dentition and frequent dental visits appears to be associated with improved overall survival among head and neck squamous cell carcinoma patients. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Mediterranean diet and the prevention of non-alcoholic fatty liver disease: results from a case-control study

Author

Giraldi, Luca, Miele, Luca, Aleksovska, K., Manca, F., Leoncini, Emanuele, Biolato, Marco, Arzani, D., Pirro, Maria Antonia, Marrone, Giuseppe, Cefalo, Chiara Maria Assunta, Racco, S., Liguori, Antonio, Rapaccini, Gian Ludovico, Miggiano, G. A., Gasbarrini, Antonio, Boccia, Stefania, and Grieco, Antonio

Subjects
Adult, Male, Epidemiology, Settore MED/12 - GASTROENTEROLOGIA, Rome, Feeding Behavior, Case-control, Middle Aged, Protective Factors, Diet, Mediterranean, Risk Assessment, Non-alcoholic Fatty Liver Disease, Risk Factors, Mediterranean diet, Prevalence, Humans, Female, Diet, Healthy, Risk Reduction Behavior, Aged, Retrospective Studies
Abstract

Few studies report that Mediterranean dietary (MD) pattern has a beneficial role in the progression of non-alcoholic fatty liver disease (NAFLD). Evidence on its potential effect on the onset of disease are, however, scanty. With our study, we evaluated whether MD affects the risk of NAFLD with a large case-control study performed in Italy.Three hundred and seventy-one cases of NAFLD and 444 controls were questioned on the demographic data and their dietary habits before diagnosis. Additionally, information about lifestyles and other related diseases, such as hypertension and diabetes mellitus were collected. The MD adherence was assessed using a pre-defined Mediterranean Diet Score (MDS). Odds ratios (OR) and 95% confidence intervals (CI) were obtained using a multiple logistic regression model.A high adherence to the MD is significantly associated with decreased risk of NAFLD (OR: 0.83 95% CI: 0.71-0.98). When the different MD components were examined separately, higher legumes consumption (OR: 0.62 95% CI: 0.38-0.99) and high fish consumption (OR 0.38 95% CI: 0.17-0.85) were reported to be protective against NAFLD.Our study shows that a high adherence to the MD decreases the risk of NAFLD.

Published
2020

3. Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

Author

Kenneth C. Johnson, Zuo-Feng Zhang, Reza Malekzadeh, Areti Lagiou, Carlo La Vecchia, Jovana Stojanovic, Nuno Lunet, Roberta Pastorino, Nuria Aragonés, Pagona Lagiou, Eva María Navarrete-Muñoz, Robert C. Kurtz, Dario Arzani, Roberto Persiani, Stefania Boccia, Guo-Pei Yu, Ana Ferro, Luca Giraldi, Claudio Pelucchi, Farhad Pourfarzi, David Zaridze, Lina Mu, Mohammadreza Pakseresht, Joshua E. Muscat, Monica Ferraroni, Matteo Rota, Dmitry Maximovich, Jesús Vioque, Eva Negri, Jinfu Hu, Domenico Palli, Vicente Martín, Giraldi, Luca, Stojanovic, Jovana, Arzani, Dario, Persiani, Roberto, Hu, Jinfu, Johnson, Kenneth C, Zhang, Zuo-Feng, Ferraroni, Monica, Palli, Domenico, Yu, Guo-Pei, La Vecchia, Carlo, Pelucchi, Claudio, Lunet, Nuno, Ferro, Ana, Malekzadeh, Reza, Muscat, Joshua, Zaridze, David, Maximovich, Dmitry, Aragones, Nuria, Martin, Vicente, Vioque, Jesù, Navarrete-Munoz, Eva M, Pakseresht, Mohammadreza, Negri, Eva, Rota, Matteo, Pourfarzi, Farhad, Mu, Lina, Kurtz, Robert C, Lagiou, Areti, Lagiou, Pagona, Pastorino, Roberta, and Boccia, Stefania

Subjects
Cancer Research, medicine.medical_specialty, biology, Epidemiology, business.industry, gastric cancer, Public Health, Environmental and Occupational Health, Cancer, Regression analysis, Odds ratio, Helicobacter pylori, medicine.disease, biology.organism_classification, Logistic regression, Confidence interval, Oncology, Medicine, adult height, business, Stomach cancer, Settore MED/42 - IGIENE GENERALE E APPLICATA, Demography
Abstract

BACKGROUND: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. METHODS: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. RESULTS: A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). CONCLUSION: Our study does not support a strong and consistent association between adult height and gastric cancer.

Published
2020

4. Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Author

Emanuele Leoncini, Tatiana Natasha Toporcov, Carlo La Vecchia, Lorenzo Simonato, Stefania Boccia, Keitaro Matsuo, Vladimir Vukovic, Luca Giraldi, Cristina Bosetti, Raquel Ayub Moyses, Dario Arzani, Diego Serraino, Gabriella Cadoni, Livia Petrelli, Yuan Chin Amy Lee, Franco Merletti, Victor Wünsch-Filho, Paolo Boffetta, Roberta Pastorino, Mia Hashibe, Leoncini, Emanuele, Vukovic, Vladimir, Cadoni, Gabriella, Giraldi, Luca, Pastorino, Roberta, Arzani, Dario, Petrelli, Livia, Wünsch-Filho, Victor, Toporcov, Tatiana Natasha, Moyses, Raquel Ayub, Matsuo, Keitaro, Bosetti, Cristina, la Vecchia, Carlo, Serraino, Diego, Simonato, Lorenzo, Merletti, Franco, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Boccia, Stefania

Subjects
Male, 0301 basic medicine, Larynx, Oncology, medicine.medical_specialty, Epidemiology, ESTUDOS MULTICÊNTRICOS, Kaplan-Meier Estimate, Neoplasms, Multiple Primary, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Interquartile range, Recurrence, Internal medicine, Preventive, medicine, Humans, Head and neck cancer, Settore MED/42 - IGIENE GENERALE E APPLICATA, Cancer, Aged, Neoplasm Staging, business.industry, Predictors, Hazard ratio, Second primary cancer, Middle Aged, medicine.disease, Confidence interval, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, Female, Settore MED/31 - OTORINOLARINGOIATRIA, Neoplasm Recurrence, Local, business, Predictor
Abstract

Recurrence and second primary cancer (SPC) continue to represent major obstacles to long-term survival in head and neck cancer (HNC). Our aim was to evaluate whether established demographics, lifestyle-related risk factors for HNC and clinical data are associated with recurrence and SPC in HNC. We conducted a multicentre study by using data from five studies members of the International Head and Neck Cancer Epidemiology consortium—Milan, Rome, Western Europe, Sao Paulo, and Japan, totalling 4005 HNC cases with a median age of 59 (interquartile range 52–67). Multivariate hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for recurrence and SPC. During follow-up, 1161 (29%) patients had recurrence and 343 (8.6%) developed SPC. Advanced tumour stage was associated with increased risk of recurrence in HNC overall (HR = 1.76, 95% CI 1.41–2.19). Women with laryngeal cancer had a reduced risk of recurrence compared to men (HR = 0.39, 95% CI: 0.24–0.74). Concerning predictors of SPC, advanced age (HR = 1.02; 95% CI: 1.00–1.04) and alcohol consumption (> 1 drink per day, HR = 2.11; 95% CI: 1.13–3.94) increased the risk of SPC among patients with laryngeal cancer. Additionally, women were at higher risk of SPC, in HNC overall group (HR = 1.68; 95% CI: 1.13–2.51) and oropharyngeal cancer group (HR = 1.74; 95% CI: 1.02–2.98). Tumour stage and male gender (larynx only) were positive predictors of cancer recurrence in HNC patients. Predictors of SPC were advanced age and alcohol use among laryngeal cancer cases, and female gender for oropharyngeal and HNC overall.

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