1. Effects of SARS-CoV-2 P.1 introduction and the impact of COVID-19 vaccination on the epidemiological landscape of São José Do Rio Preto, Brazil
- Author
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Rafael Alves da Silva, Maisa Carla Pereira Parra, Fernanda Simoes Dourado, Benjamin M. Althouse, Gislaine Celestino Dutra da Silva, Victor Miranda Hernandes, Nathalia Zini, Alice F. Versiani, Leila Sabrina Ullmann, Paula Rahal, Cíntia Bittar, Edoardo Estevam de Oliveira Lobl, Cecilia Artico Banho, Fábio Sossai Possebon, Michela Dias Barcelos, Leonardo Cecílio da Rocha, Guilherme Campos, Jamie A. Cohen, Nikos Vasilakis, Caio Patuto, Bruno Henrique Gonçalves de Aguiar Milhim, Lívia Sacchetto, Ana Carolina Boldrin, Beatriz de Carvalho Marques, Maurício Lacerda Nogueira, Marilia Mazzi Moraes, Victoria Bernardi Ciconi, João Pessoa Araújo, Cássia Fernanda Estofolete, Andresa Lopes dos Santos, Helena Lage Ferreira, Andreia Francesli Negri, Carolina Colombelli Pacca, and Thayza dos Santos
- Subjects
education.field_of_study ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Population ,Vaccination ,Epidemiology ,medicine ,education ,business ,Beneficial effects ,Demography - Abstract
The emergence of the new Brazilian variant of concern, P.1 lineage (Gamma), raised concern about its impact on the epidemiological profile of COVID-19 cases due to its higher transmissibility rate and immune evasion ability. Using 272 whole-genome sequences combined with epidemiological data, we showed that P.1 introduction in São José do Rio Preto, São Paulo, Brazil, was followed by the displacement of eight circulating SARS-CoV-2 variants and a rapid increase in prevalence two months after its first detection. Our findings support that the P.1 variant is associated with an increase in mortality risk and severity of COVID-19 cases in younger aged groups, which corresponds to the unvaccinated population at the time. Moreover, our data highlight the beneficial effects of vaccination indicated by a pronounced reduction of severe cases and deaths in immunized individuals, reinforcing the need for rapid and massive vaccination.
- Published
- 2021
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