1. APOBECs orchestrate genomic and epigenomic editing across health and disease.
- Author
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Cervantes-Gracia K, Gramalla-Schmitz A, Weischedel J, and Chahwan R
- Subjects
- Cytidine Deaminase genetics, Cytidine Deaminase metabolism, Genome, Genomics, Retroelements, APOBEC Deaminases genetics, APOBEC Deaminases metabolism, Epigenomics
- Abstract
APOBEC proteins can deaminate cytosine residues in DNA and RNA. This can lead to somatic mutations, DNA breaks, RNA modifications, or DNA demethylation in a selective manner. APOBECs function in various cellular compartments and recognize different nucleic acid motifs and structures. They orchestrate a wide array of genomic and epigenomic modifications, thereby affecting various cellular functions positively or negatively, including immune editing, viral and retroelement restriction, DNA damage responses, DNA demethylation, gene expression, and tissue homeostasis. Furthermore, the cumulative increase in genomic and epigenomic editing with aging could also, at least in part, be attributed to APOBEC function. We synthesize our cumulative understanding of APOBEC activity in a unifying overview and discuss their genomic and epigenomic impact in physiological, pathological, and technological contexts., Competing Interests: Declaration of interests The authors declare no conflicts of interest., (Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2021
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