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Your search keyword '"Özkara, Cigdem"' showing total 2 results
Start Over Author "Özkara, Cigdem" Topic epilepsy surgery
2 results on '"Özkara, Cigdem"'

1. Cavernoma‐related epilepsy: Review and recommendations for management—Report of the Surgical Task Force of the ILAE Commission on Therapeutic Strategies

Author

Rosenow, Felix, Alonso‐Vanegas, Mario A, Baumgartner, Christoph, Blümcke, Ingmar, Carreño, Maria, Gizewski, Elke R, Hamer, Hajo M, Knake, Susanne, Kahane, Philippe, Lüders, Hans O, Mathern, Gary W, Menzler, Katja, Miller, Jonathan, Otsuki, Taisuke, Özkara, Cigdem, Pitkänen, Asla, Roper, Steven N, Sakamoto, Americo C, Sure, Ulrich, Walker, Matthew C, Steinhoff, Bernhard J, and Force, Commission on Therapeutic Strategies of the ILAE The Surgical Task

Subjects
Epilepsy, Neurodegenerative, Brain Disorders, Neurosciences, Neurological, Anticonvulsants, Brain, Brain Neoplasms, Hemangioma, Cavernous, Central Nervous System, Humans, Neuroimaging, Risk Factors, Cavernous hemangioma, Epilepsy surgery, Etiology, Risk factors, Outcome, Surgical Task Force, Commission on Therapeutic Strategies of the ILAE, Clinical Sciences, Neurology & Neurosurgery
Abstract

Cerebral cavernous malformations (CCMs) are well-defined, mostly singular lesions present in 0.4-0.9% of the population. Epileptic seizures are the most frequent symptom in patients with CCMs and have a great impact on social function and quality of life. However, patients with CCM-related epilepsy (CRE) who undergo surgical resection achieve postoperative seizure freedom in only about 75% of cases. This is frequently because insufficient efforts are made to adequately define and resect the epileptogenic zone. The Surgical Task Force of the Commission on Therapeutics of the International League Against Epilepsy (ILAE) and invited experts reviewed the pertinent literature on CRE. Definitions of definitive and probable CRE are suggested, and recommendations regarding the diagnostic evaluation and etiology-specific management of patients with CRE are made. Prospective trials are needed to determine when and how surgery should be done and to define the relations of the hemosiderin rim to the epileptogenic zone.

Published
2013

2. Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe

Author

Mouthaan, Brian E, Rados, Matea, Barsi, Péter, Boon, Paul, Carmichael, David W, Carrette, Evelien, Craiu, Dana, Cross, J Helen, Diehl, Beate, Dimova, Petia, Fabo, Daniel, Francione, Stefano, Gaskin, Vladislav, Gil-Nagel, Antonio, Grigoreva, Elena, Guekht, Alla, Hirsch, Edouard, Hecimovic, Hrvoje, Helmstaedter, Christoph, Jung, Julien, Kalviainen, Reetta, Kelemen, Anna, Kimiskidis, Vasilios, Kobulashvili, Teia, Krsek, Pavel, Kuchukhidze, Giorgi, Larsson, Pål G, Leitinger, Markus, Lossius, Morten I, Luzin, Roman, Malmgren, Kristina, Mameniskiene, Ruta, Marusic, Petr, Metin, Baris, Özkara, Cigdem, Pecina, Hrvoje, Quesada, Carlos M, Rugg-Gunn, Fergus, Rydenhag, Bertil, Ryvlin, Philippe, Scholly, Julia, Seeck, Margitta, Staack, Anke M, Steinhoff, Bernhard J, Stepanov, Valentin, Vos, Sjoerd B, Huiskamp, Geertjan, Leijten, Frans S S, Van Eijsden, Pieter, Braun, Kees P J, and E-PILEPSY consortium

Subjects
Multicenter Study, Positron emission tomography, Magnetic resonance imaging, Epilepsy surgery, Electromagnetic source imaging, Journal Article, Single-photon emission computed tomography
Abstract

OBJECTIVE: In 2014 the European Union-funded E-PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic source localization, and imaging postprocessing procedures in participating centers. METHODS: A survey on the clinical use of imaging, electromagnetic source localization, and postprocessing methods in epilepsy surgery candidates was distributed among the 25 centers of the consortium. A descriptive analysis was performed, and results were compared to existing guidelines and recommendations. RESULTS: Response rate was 96%. Standard epilepsy magnetic resonance imaging (MRI) protocols are acquired at 3 Tesla by 15 centers and at 1.5 Tesla by 9 centers. Three centers perform 3T MRI only if indicated. Twenty-six different MRI sequences were reported. Six centers follow all guideline-recommended MRI sequences with the proposed slice orientation and slice thickness or voxel size. Additional sequences are used by 22 centers. MRI postprocessing methods are used in 16 centers. Interictal positron emission tomography (PET) is available in 22 centers; all using 18F-fluorodeoxyglucose (FDG). Seventeen centers perform PET postprocessing. Single-photon emission computed tomography (SPECT) is used by 19 centers, of which 15 perform postprocessing. Four centers perform neither PET nor SPECT in children. Seven centers apply magnetoencephalography (MEG) source localization, and nine apply electroencephalography (EEG) source localization. Fourteen combinations of inverse methods and volume conduction models are used. SIGNIFICANCE: We report a large variation in the presurgical diagnostic workup among epilepsy surgery centers across Europe. This diversity underscores the need for high-quality systematic reviews, evidence-based recommendations, and harmonization of available diagnostic presurgical methods.

Published
2016

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