1. Supplementation of heat‐inactivated <italic>Bacillus clausii</italic> DE5 in diets for grouper, <italic>Epinephelus coioides,</italic> improves feed utilization, intestinal and systemic immune responses and not growth performance.
- Author
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Wang, J., Yang, H.‐L., Xia, H.‐Q., Ye, J.‐d., Lu, K.‐L., Hu, X., Feng, Y., Ruan, L., and Sun, Y.‐Z.
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IMMUNE response in fishes , *BACILLUS (Bacteria) , *FEED utilization efficiency , *BACTERIAL inactivation , *DIETARY supplements , *INTESTINAL physiology , *EPINEPHELUS - Abstract
Abstract: In recent years, more and more attentions have been paid to the development and application of probiotics in aquaculture, and viable probiotics have been extensively studied, while rare information was available about inactivated probiotics in aquaculture. Therefore, in this study, a feeding trial was designed to investigate the effect of dietary supplementation of heat‐inactivated probiotic
Bacillus clausii DE5 on growth performance, immune response and key immune genes expression in head kidney and intestine in grouperEpinephelus coioides . Fish were fed for 60 days with control diet (C) and two experimental diets containing 1.0 × 108 CFU/g live (T1) and heat‐inactivated (T2)B. clausii DE5, respectively. The probiotic treatments did not affect the final weight, weight gain (WG) and specific growth rate (SGR) ofE. coioides at days 30 and 60 (p >B. clausii DE5 significantly decreased the feed intake and feed conversion ratio (FCR) at day 60 (p <p <p <B. clausii DE5 significantly improved the expression of TLR5, pro‐inflammatory cytokines (IL‐8 and IL‐1β) and TGF‐β1 in head kidney and intestine (p <B. clausii DE5 effectively improved feed utilization and both the local and systemic immune responses ofE. coioides . [ABSTRACT FROM AUTHOR]- Published
- 2018
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