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Increasing evidence advocates the prognostic role of RDW in various tumours. We analysed 591 patients to assess whether RDW is a prognostic factor for overall (OS) and cancer-related survival (CRS) for patients with colorectal cancer (CRC). The data were retrieved from a retrospective database. The optimal cut-off value for RDW was set at 14.1%; accordingly, two groups were considered: those with a value equal or lower than 14.1% (L-RDW), and those with a value higher than 14.1% (H-RDW). The mean value of RDW rose from pT1 to pT4 tumours. H-RDW correlated with age above the mean, colonic location of the lesion, pT and TNM stage. Finally, H-RDW was significantly associated with the intent of surgery: almost 50% of patients who underwent a non-curative resection presented H-RDW, compared to 19.3% in R0 resections. OS was significantly lower in patients with H-RDW. CRS was similar in the two groups. Stratifying patients according to TNM stage worse OS was associated with H-RDW only in early stages, whereas there was no difference for stages II-IV. Multivariate analysis confirmed that H-RDW was not an independent prognostic factor. Although H-RDW correlated with some negative clinical-pathological factors, it did not seem to independently influence OS and CRS. [ABSTRACT FROM AUTHOR]

The aim of this study was to investigate its role as a prognostic factor for overall (OS) and cancer-related survival (CRS) in patients who underwent surgery for colorectal cancer (CRC). B Materials and Methods: b From January 2005 to December 2016, 1347 patients underwent surgery for CRC at the Division of General and Hepatobiliary Surgery, University of Verona Hospital Trust. Patients with evidence of infection or inflammatory conditions, and those who underwent emergency surgery were excluded; the minimum follow-up time was 24 months. [Extracted from the article]

Nonetheless, little data are available on the use of red blood cell (RBC) transfusions after laparoscopic and open CRC resection. The hypothesis of this case-matched study is that postoperative RBC requirement in patients undergoing elective resection for CRC is lower after laparoscopic compared to open surgery The total number of transfused RBC units was significantly higher after open surgery (353 vs. 180; p<0.01), while the mean(SD) number of units for transfused patients was comparable between the two groups [4.4 (3.7) vs 3.7 (3.4); p = 0.79]. [Extracted from the article]