1. High expression of uPA related to p38MAPK in esophageal cancer indicates poor prognosis
- Author
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Liu Q, Li W, Yang S, and Liu Z
- Subjects
mitogen-activated protein kinase 38 (p38MAPK) ,esophageal cancer ,prognosis ,urokinase-type plasminogen activator (uPA) ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 - Abstract
Qilong Liu,1,* Wenfeng Li,1,* Shibin Yang,1 Zhaoguo Liu2 1Department of Gastrointestinal Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510089, Guangdong, China; 2Department of General Thoracic Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510089, Guangdong, China *These authors contributed equally to this work Background: The aim of the study was to investigate the relationship between urokinase-type plasminogen activator (uPA) and mitogen-activated protein kinase 38 (p38MAPK), and preliminarily analyze their relationship with clinical characteristics of esophageal cancer. Materials and methods: Immunohistochemistry and Western blot were used to detect the expressions of uPA and p38MAPK in patients with esophageal cancer. The relationship between them and clinicopathological features was analyzed by chi-squared test and Spearman correlation. Prognosis was performed using Kaplan–Meier and Cox proportional hazard models analysis. Results: The expressions of uPA and p38MAPK proteins were significantly higher in esophageal squamous cell carcinoma or adenocarcinoma than in normal esophageal mucosa tissue (both P
- Published
- 2018