1. Role of vascular endothelial growth factor in radiotherapy resistance to esophageal squamous cell carcinoma.
- Author
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Li X, Su X, Yan C, Ma Y, Li H, Xia J, Li H, Jiang Q, Zhou L, and Zou Z
- Subjects
- Humans, Vascular Endothelial Growth Factor A genetics, Vascular Endothelial Growth Factors therapeutic use, Cell Line, Tumor, Esophageal Squamous Cell Carcinoma radiotherapy, Esophageal Neoplasms genetics, Esophageal Neoplasms radiotherapy, Esophageal Neoplasms metabolism, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell radiotherapy, Carcinoma, Squamous Cell metabolism
- Abstract
Vascular endothelial growth factor (VEGF) is related to the radiation resistance of tumors, resulting in the failure of tumor radiotherapy. The purpose of this study was to discuss the role of VEGF in radiotherapy resistance of esophageal squamous cell carcinoma (ESCC). We used the VEGF kit by ELISA to detect the serum VEGF level of ESCC patients who only received radiotherapy. The expression of VEGF in ESCC cells after siRNA treatment was verified by Western blot. The sensitivity of ESCC cells to radiation after knocking down VEGF was analyzed by Clonogenic assay and Cell counting kit (CCK-8). The results showed that the level of serum VEGF in patients with ESCC before and after radiotherapy was related to the clinical response, and it was confirmed that knocking down the expression of VEGF in ESCC cells improved the sensitivity to radiation., (© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2023
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