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Your search keyword '"Akhlaq M"' showing total 3 results
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3 results on '"Akhlaq M"'

1. Controlled release matrix tablets of glipizide: Influence of different grades of ethocel and Co-excipient on drug release.

Author

Mehsud SU, Khan GM, Hussain A, Akram M, Akhlaq M, Khan KA, and Shakoor A

Subjects
Calorimetry, Differential Scanning, Carboxymethylcellulose Sodium chemistry, Cellulose chemistry, Chemistry, Pharmaceutical, Delayed-Action Preparations, Hydrophobic and Hydrophilic Interactions, Hypromellose Derivatives chemistry, Kinetics, Models, Chemical, Powders, Solubility, Starch chemistry, Tablets, Technology, Pharmaceutical methods, Cellulose analogs & derivatives, Excipients chemistry, Glipizide chemistry, Hypoglycemic Agents chemistry
Abstract

The aim of the current study was to formulate and evaluate glipizide controlled release matrix tablets by means of different grades of polymer Ethoceland different co-excipients in order to evaluate their effect on drug release profiles during in vitro dissolution studies. Type II diabetes mellitus is usually treated with Glipizide. Glipizide belongs to sulfonylurea group. Gastric disturbance and severe hypoglycemia has been observed after taking glipizide orally. To overcome these problems, controlled release matrices were developed using different grades of ethyl cellulose polymer with a drug-polymer ratio of 1:3by the direct compression method. The effect on drug release of partial replacement of lactose by different co-excipients, HPMC K100M, starch and CMC, were also studied. Diameter, thickness, hardness, friability, weight variations, drug contents of formulations were tested, these properties were within prescribed limits. Co-excipients and polymer containing formulations were compared to the without co-excipients and polymer containing formulations with respect to their release profile. After a 24-hour release study, ethyl cellulose polymer containing formulation exhibited prolonged release for 5-16 hours; however the polymer Ethocel (R) standard FP 7 Premium without co-excipient containing formulation exhibited controlled release for 24 hours. Incompatibility was investigated between drugs, co-excipient DSC and polymer study was performed and any type of interaction was not found. Different kinetic models were used to study the release mechanism. An enhanced release rate was observed in case of excipients containing formulations.

Published
2016

2. Formulation, and physical, in vitro and ex vivo evaluation of transdermal ibuprofen hydrogels containing turpentine oil as penetration enhancer.

Author

Khan NR, Khan GM, Wahab A, Khan AR, Hussain A, Nawaz A, and Akhlaq M

Subjects
Administration, Cutaneous, Animals, Chemistry, Pharmaceutical, Hydrogels, Hydrogen-Ion Concentration, In Vitro Techniques, Irritants, Rabbits, Skin drug effects, Skin pathology, Solubility, Viscosity, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal chemistry, Excipients chemistry, Ibuprofen administration & dosage, Ibuprofen chemistry, Skin Absorption drug effects, Turpentine chemistry
Abstract

The aim of the present study was to investigate the transdermal permeation enhancing capability of turpentine oil for ibuprofen from hydrogels. Ibuprofen 1% w/v hydrogels were developed with carboxypolymethylene with and without turpentine oil. Turpentine oil was incorporated in increasing concentrations, i.e. 0.5, 1, 1.5, 2, 2.5 and 3% of the total gel formulation, and its permeation enhancing effect was examined. Gels were examined physically for pH, viscosity, spreadability, extrudability, smoothness and appearance. To study the in vitro and ex vivo permeation potential of formulated gels, permeation studies were performed with a Franz diffusion cell using cellulose membrane and excised rabbit abdominal skin. Ibuprofen hydrogel with 3% turpentine oil showed a maximum flux of 10.87 mg/cm2/h across artificial skin and 17.26 mg/cm2/h across rabbit abdominal skin.

Published
2011

3. Formulation and evaluation of controlled release matrices of ketoprofen and influence of different co-excipients on the release mechanism

Author

Wahab A, Gm, Khan, Akhlaq M, Nr, Khan, Hussain A, Mf, Khan, and Khan H

Subjects
Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Anti-Inflammatory Agents, Non-Steroidal, Temperature, Starch, Methylcellulose, Excipients, Kinetics, Hypromellose Derivatives, Solubility, Ketoprofen, Delayed-Action Preparations, Spectroscopy, Fourier Transform Infrared, Indicators and Reagents, Cellulose, Algorithms, Tablets
Abstract

The present work reports the study of different controlled release formulations of ketoprofen, which is a non-steroidal anti-inflammatory drug (NSAID) and like other NSAIDs requires large and frequent daily doses, resulting in severe side effects and non-compliance. To avoid these problems, controlled release matrices were developed using different grades of ethylcellulose polymer with a drug-polymer ratio of 10:3 by the direct compression method. The effect on drug release of partial replacement of lactose by different co-excipients, HPMC K100 M, starch and CMC, was also studied. The tablets were tested for their drug content, weight variation, friability, hardness, thickness and diameter, all these physical properties being within the USP range. The release profile of all formulations containing polymer and co-excipients was compared with a formulation developed without polymer and co-excipients. After a 24-hour release study, it was concluded that formulations containing different grades of ethylcellulose polymer showed prolonged release for 6-18 hours, but the formulation containing the polymer Ethocel standard FP 7 Premium without co-excipient showed controlled release for 24 hours. DSC and FT-IR studies were performed to investigate any incompatibility between drug, polymer and co-excipient but no interaction was found. Different kinetic models were used, such as first order equation, zero order equation, Higuachi equation, Hixon Crowel's equation and Korsmeyer-Peppas to study the release mechanism. The formulations containing co-excipients showed an enhanced release rate.

Published
2011

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