1. Exercise immunology meets MiRNAs.
- Author
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Makarova JA, Maltseva DV, Galatenko VV, Abbasi A, Maximenko DG, Grigoriev AI, Tonevitsky AG, and Northoff H
- Subjects
- Adult, Animals, Biomarkers, Coronary Disease blood, Coronary Disease physiopathology, Forecasting, Gene Expression Profiling, Humans, Inflammation blood, Inflammation immunology, Male, MicroRNAs blood, MicroRNAs genetics, Muscle, Skeletal metabolism, Rats, Spinal Cord Injuries blood, Spinal Cord Injuries physiopathology, Exercise physiology, Immune System physiology, Leukocytes metabolism, MicroRNAs physiology
- Abstract
A large body of evidence indicates modified expression of protein-coding genes in response to different kinds of physical activity. Recent years have exposed another level of regulation of cellular processes mediated by non-coding RNAs. MicroRNAs (miRNAs) are one of the largest families of non-coding RNAs. MiRNAs mediate post-transcriptional regulation of gene expression. The amount of data supporting the key role of miRNAs in the adaptation of the immune and other body systems to exercise steadily grows. MiRNAs change their expression profiles after exercise and seem to be involved in regulation of exercise-responsive genes in immune and other cell types. Here we discuss existing data and future directions in the field.
- Published
- 2014