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Physical activity level (PAL) and sedentary behavior (SB) are independent predictors of mortality. It is unclear how these predictors interact with each other and health variables. Investigate the bidirectional relationship between PAL and SB, and their impact and health variables of women aged 60 to 70 years. One hundred forty-two older adults women (66.3 ± 2.9 years) considered insufficiently active were submitted to 14 weeks of multicomponent training (MT), multicomponent training with flexibility (TMF), or the control group (CG). PAL variables were analyzed by accelerometry and QBMI questionnaire, physical activity (PA) light, moderate, vigorous and CS by accelerometry, 6 min walk (CAM), SBP, BMI, LDL, HDL, uric acid, triglycerides, glucose and cholesterol total. In linear regressions, CS was associated with glucose (B:12.80; CI:9.31/20.50; p  < 0.001; R 2 :0.45), light PA (B:3.10; CI:2, 41/4.76; p  < 0.001; R 2 :0.57), NAF by accelerometer (B:8.21; CI:6.74/10.02; p  < 0.001; R 2 :0.62), vigorous PA (B:794.03; CI:682.11/908.2; p  < 0.001; R 2 :0.70), LDL (B:13.28; CI:7.45/16.75; p  < 0.002; R 2 :0.71) and 6 min walk (B:3.39; CI:2.96/8.75; p  < 0.004; R 2 :0.73). NAF was associated with mild PA (B:0.246; CI:0.130/0.275; p  < 0.001; R 2 :0.624), moderate PA (B:0.763; CI:0.567/0.924; p  < 0.001; R 2 :0.745), glucose (B:-0.437; CI:-0.789/-0.124; p  < 0.001; R 2 :0.782), CAM (B:2.223; CI:1.872/4.985; p  < 0.002; R 2 :0.989) and CS (B:0.253; CI: 0.189/0.512; p  < 0.001; R 2 :1.94). The NAF can enhance CS. Build a new look at how these variables are independent but dependent simultaneously, being able to influence the quality of health when this dependence is denied., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 de Oliveira, Sobrinho, Benjamim, da Silva Rodrigues, Rodrigues, Fernandes, Corrêa, Felicio, de Oliveira Gomes and Júnior.)

Exercise training emerges as a key strategy in lifestyle modification, capable of reducing the risk of developing Alzheimer's disease (AD) due to risk factors such as age, family history, genetics and low level of education associated with AD. We aim to analyze the effect of a 14-week combined exercise training (CT) on the methylation of genes associated with AD in non-alzheimer's disease women. CT sessions lasted 60 min, occurring three times a week for 14 weeks. Forty non-Alzheimer's disease women aged 50 to 70 years (60.7 ± 4.1 years) with a mean height of 1.6 ± 0.1 m, mean weight of 73.12 ± 9.0 kg and a mean body mass index of 29.69 ± 3.5 kg/m2, underwent two physical assessments: pre and post the 14 weeks. DNA methylation assays utilized the EPIC Infinium Methylation BeadChip from Illumina. We observed that 14 weeks of CT led to reductions in systolic (p = 0.001) and diastolic (p = 0.017) blood pressure and improved motor skills post-intervention. Among 25 genes linked to AD, CT induced differentially methylated sites in 12 genes, predominantly showing hypomethylated sites (negative β values). Interestingly, despite hypomethylated sites, some genes exhibited hypermethylated sites (positive β values), such as ABCA7 , BDNF , and WWOX. A 14-week CT regimen was adequate to induce differential methylation in 12 CE-related genes in healthy older women, alongside improvements in motor skills and blood pressure. In conclusion, this study suggest that combined training can be a strategy to improve physical fitness in older individuals, especially able to induce methylation alterations in genes sites related to development of AD. It is important to highlight that training should act as protective factor in older adults. • For 14 weeks acted on 12 genes, that may be protective factor in the development of AD; • Exercise training improved functional capacity, physical performance and blood pressure in women aged between 50 and 70 years. [ABSTRACT FROM AUTHOR]