3 results on '"Orsatti, Cláudio Lera"'
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2. Effects of isoflavone and counter-resistance training on bone mineral density in postmenopausal women
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Orsatti, Fábio Lera, Nahás, Eliana Aguiar Petri [UNESP], Nahas-neto, Jorge [UNESP], Orsatti, Cláudio Lera [UNESP], Teixeira, Altamir Santos [UNESP], Universidade Federal do Triângulo Mineiro (UFTM), and Universidade Estadual Paulista (Unesp)
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Soy ,Soja ,Exercício ,Osteocalcin ,Menopause ,Exercise ,Menopausa ,Osteocalcina - Abstract
Made available in DSpace on 2014-10-01T13:08:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-12-01Bitstream added on 2014-10-01T14:03:04Z : No. of bitstreams: 1 S1980-00372013000600010.pdf: 180906 bytes, checksum: 766b96c54a6757f96b9b5ed973175b72 (MD5) O estudo teve como objetivo investigar o efeito isolado e combinado do treinamento contrarresistência (TCR) e da suplementação de isoflavona da soja (ISO) sobre a densidade mineral óssea (DMO) e a remodelação óssea em mulheres na pós-menopausa (MPM). Tratou-se de estudo clínico, prospectivo, placebo-controlado, duplo-cego (ISO) e randomizado, envolvendo 80 MPM sedentárias, com idade entre 45-70 anos, randomizadas em quatro grupos (71 completaram nove meses): TCR+ISO (n=15); sem TCR+ISO (n=20); TCR+ placebo (n=18); sem TCR + placebo (n=18). As participantes randomizadas no grupo ISO receberam 100mg/dia/VO (via oral) de isoflavona e as no grupo TCR realizaram sessões supervisionadas de exercícios contrarresistência (mínimo de 2 dias/ semana). Nos momentos inicial e final do estudo, a DMO do colo do fêmur e da coluna lombar foram estimadas pela absortometria radiológica de feixes duplos de energia (DXA) e a força muscular pelo teste de 1-RM. Os valores plasmáticos de telopeptídeos carboxiterminais do colágeno tipo I (CTX), osteocalcina e fator de crescimento semelhante à insulina (IGF-1) foram dosados como marcadores de remodelação óssea. Após 9 meses de intervenção não foram observados efeitos independentes ou aditivos do TCR e ISO sobre a DMO bem como sobre os valores de osteocalcina, CTX e IGF-1 (p>0,05). Houve aumento da força muscular (+ 35,2%) somente nos grupos submetidos ao TCR (p=0,02). Conclui-se que o TCR e ISO não apresentam efeitos combinados ou independentes sobre a DMO do fêmur e da coluna lombar e marcadores da remodelação óssea em MPM após nove meses de intervenção. This study aimed to investigate the independent and additive effects of counter-resistance training (RT) and soy isoflavone supplement (ISO) on bone mineral density (BMD) and bone turnover in postmenopausal women. This study used a placebo-controlled, double-blinded (soy), randomized two (ISO vs. placebo) x two (RT vs. no RT) design. Eighty sedentary postmenopausal women, aged 45-70 years, were randomly assigned to one of four groups (71 completed a 9-month intervention): RT+ISO (n=15); no RT+ISO (n=20); RT+placebo (n=18); no RT+placebo (n=18). Participants randomized to ISO received 100mg/ day/oral of soy isoflavone; and those to RT attended supervised counter-resistance training sessions at least twice a week. At baseline and 9-month, BMD was estimated by dual-energy X-ray absorptiometry (DXA). Serum levels of C-terminal cross-linked telopeptide of type I collagen (CTX), osteocalcin, and insulin-like growth factor-1 (IGF-1) were measured as bone turnover. ANOVA with time as the repeated measure and test t were used in the statistical analysis. After 9 months of intervention, neither ISO nor RT alone affected BMD at any site or levels of CTX, osteocalcin, and IGF-1 (p>0.05). ISO and RT had no additive effects on BMD and bone turnover. RT groups showed significantly increased muscle strength (+ 35.2%) (p=0.02). We found no additive effects of resistance training and soy isoflavone on bone mineral density or bone turnover in postmenopausal women after 9-months. Universidade Federal do Triângulo Mineiro Instituto de Ciências da Saúde Departamento de Ciências do Esporte Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu Departamento de Ginecologia e Obstetrícia Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina Departamento de Doenças Tropicais e Diagnóstico por Imagem Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina de Botucatu Departamento de Ginecologia e Obstetrícia Universidade Estadual Paulista Júlio de Mesquita Filho Faculdade de Medicina Departamento de Doenças Tropicais e Diagnóstico por Imagem
- Published
- 2013
3. Heterogeneity in resistance training-induced muscle strength responses is associated with training frequency and insulin resistance in postmenopausal women.
- Author
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Orsatti, Fábio Lera, Nunes, Paulo Ricardo Prado, Carneiro, Marcelo Augusto da Silva, Orsatti, Cláudio Lera, and Souza, Markus Vinícius Campus
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MUSCLE strength , *POSTMENOPAUSE , *INSULIN resistance , *SARCOPENIA , *THERAPEUTICS - Abstract
In older adults, muscle strength (MS), a key component of sarcopenia, is essential to maintaining independence and physical capacity. The rate of MS decline typically accelerates during the menopausal transition. Although MS has been shown to increase with resistance training (RT), the response to training is quite heterogeneous. Thus, if contributing factors to RT non-responsiveness to MS gains are identified, it may be possible to develop more effective and personalized ways to improve MS or identify individuals who may benefit from RT interventions. This study assessed potential factors that may contribute to MS response heterogeneity in postmenopausal women: training frequency, serum FSH and estrogen levels, adiposity, inflammation marker, and insulin resistance. One hundred and thirteen individuals participated in a 16-week program of supervised RT (3 sets, 8–12 repetitions, and 2–3 times/week). A control group (CTL, n = 63 – no performed the RT) was used as the comparator arm. Body composition (skinfold) and blood samples (metabolic and inflammatory indicators and hormones) were measured at baseline. Knee extensor strength (1RM) was measured at baseline, 8 weeks, and 16 weeks. Only the RT group increased 1RM after 8 weeks (RT = 14 ± 12% vs. CTL = 6 ± 15%). Both groups increased 1RM after 16 weeks, with the RT group showing a greater increase than the CTL group (RT = 31 ± 23% vs CTL = 13 ± 25%). After 8 weeks of RT, 41 (36% of total) individuals were considered non-responders (based on control group responses) and 27 (24% of total) individuals after 16 weeks. At week 8, lower RT frequency (2 times/week vs. 3 times/week) was associated with higher odds of being non-responder (3 times, P = 0.048). At week 16, lower RT frequency (13 times, P = 0.009) and higher HOMA-IR (for every unit increase, odds increase by 40%, P = 0.022) were associated with higher odds of being non-responder. Higher QUICKI was associated with lower odds of being non-responder (for every unit increase, odds decrease by 16%, P = 0.039). Moreover, higher RT frequency (17 times, P = 0.028) and higher QUICKI (for every unit increase, odds increase by 41%, P = 0.017) were associated with higher odds of becoming a responder at week 16, being a non-responder at week 8. Heterogeneity in RT-induced MS responses is associated with training frequency and insulin resistance in postmenopausal women. • Response to resistance training (RT) is heterogeneous in postmenopausal women (PW). • RT non-response to muscle strength (MS) gains seem to be mitigated by higher RT frequency. • Insulin resistance seems to contribute to RT non-responsiveness to MS gains. • FSH, E 2 , CRP, adiposity seem not to contribute to RT non-response to MS gains. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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