1. Macrophage Plasticity and Function in the Eye and Heart.
- Author
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Wang Z, Koenig AL, Lavine KJ, and Apte RS
- Subjects
- Aging immunology, Animals, Cardiovascular Diseases pathology, Eye Diseases pathology, Homeostasis immunology, Humans, Cardiovascular Diseases immunology, Cell Plasticity immunology, Eye Diseases immunology, Macrophage Activation immunology, Macrophages immunology
- Abstract
Macrophages are important mediators of inflammation and tissue remodeling. Recent insights into the heterogeneity of macrophage subpopulations have renewed interest in their functional diversity in homeostasis and disease. In addition, their plasticity enables them to perform a variety of functions in response to changing tissue contexts, such as those imposed by aging. These qualities make macrophages particularly intriguing cells given their dichotomous role in protecting against, or accelerating, diseases of the cardiovascular system and the eye, two tissues that are particularly susceptible to the effects of aging. We review novel perspectives on macrophage biology, as informed by recent studies detailing the diversity of macrophage identity and function, as well as mechanisms influencing macrophage behavior that might offer opportunities for new therapeutic strategies., (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Published
- 2019
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