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Start Over Author "Kanji Takahashi, MD, PhD" Topic eye drops
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1. Phase I Study of Tivozanib Eye Drops in Healthy Volunteers and Patients with Neovascular Age-Related Macular Degeneration

Author

Fumi Gomi, MD, PhD, Tomohiro Iida, MD, PhD, Ryusaburo Mori, MD, PhD, Shinya Horita, PhD, MBA, Hiroaki Nakamura, MS, Yu Nakajima, MMath, Ayako Shiokawa, BPharm, and Kanji Takahashi, MD, PhD

Subjects
Anti-VEGF, Eye drops, Neovascular age-related macular degeneration, Tivozanib, VEGFR tyrosine kinase inhibitors, Ophthalmology, RE1-994
Abstract

Purpose: To evaluate the safety, pharmacokinetics, and exploratory efficacy of tivozanib eye drops in healthy volunteers and patients with neovascular age-related macular degeneration (nAMD). Design: This multicenter group-sequential dose escalation phase I study consisted of a placebo-controlled double-masked study of healthy volunteers (cohorts 1 and 2) and an open-label study of patients with nAMD (cohort 3). Participants: Healthy volunteers: Japanese or White men aged 20 to

Published
2024
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