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Your search keyword '"Retinoblastoma congenital"' showing total 6 results
Start Over Descriptor "Retinoblastoma congenital" Topic eye neoplasms
6 results on '"Retinoblastoma congenital"'

1. Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome.

Author

Hon C, Chan GC, Ha SY, Ma SK, Wong KF, and Au WY

Subjects
Acute Disease, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Carboplatin administration & dosage, Cryosurgery, Cryotherapy, Cyclosporine administration & dosage, DNA-Binding Proteins genetics, Enzyme Inhibitors administration & dosage, Eye Neoplasms congenital, Eye Neoplasms genetics, Eye Neoplasms radiotherapy, Eye Neoplasms surgery, Female, Histone-Lysine N-Methyltransferase, Humans, Infant, Newborn, Leukemia, Myeloid chemically induced, Leukemia, Myeloid genetics, Myeloid-Lymphoid Leukemia Protein, Neoplasm Proteins antagonists & inhibitors, Neoplasm Proteins genetics, Neoplasm Recurrence, Local, Neoplasms, Multiple Primary congenital, Neoplasms, Multiple Primary genetics, Neoplasms, Multiple Primary radiotherapy, Neoplasms, Multiple Primary surgery, Neoplasms, Second Primary chemically induced, Remission Induction, Retinoblastoma congenital, Retinoblastoma genetics, Retinoblastoma radiotherapy, Retinoblastoma surgery, Teniposide administration & dosage, Topoisomerase II Inhibitors, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols adverse effects, Chromosome Deletion, Chromosomes, Human, Pair 13 ultrastructure, Enzyme Inhibitors adverse effects, Eye Neoplasms drug therapy, Leukemia, Myeloid therapy, Neoplasms, Multiple Primary drug therapy, Neoplasms, Second Primary therapy, Peripheral Blood Stem Cell Transplantation, Proto-Oncogenes, Retinoblastoma drug therapy, Transcription Factors
Abstract

Children with constitutional deletion of the long arm of chromosome 13 are at risk for retinoblastoma (RB) due to loss of the RB tumor suppressor gene. The prognosis is poor since the tumors are often bilateral, aggressive, and recurrent and the patients often harbor other congenital abnormalities. One further complication is that of therapy-related malignancies later in life. We report a case of allogeneic stem cell transplantation for therapy-related acute myeloid leukemia in an 8-year-old girl after multimodality treatment for refractory bilateral relapsing RB, with excellent outcome in both the ophthalmic and marrow disease.

Published
2004
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2. A giant congenital orbital tumor: an unusual presentation of retinoblastoma.

Author

Zwaan CM, de Waal FC, Koole FD, Menko FH, van der Valk P, Slater RM, Scheffer H, van Waveren G, Moll AC, and Schouten-van Meeteren AY

Subjects
Eye Neoplasms pathology, Humans, Infant, Newborn, Neoplasm Invasiveness, Neoplasm Recurrence, Local pathology, Orbital Neoplasms pathology, Retinoblastoma pathology, Eye Neoplasms congenital, Orbital Neoplasms congenital, Retinoblastoma congenital
Abstract

We report a case of an unusual giant congenital tumor presenting in a newborn infant as a large exophytic mass emerging from the left orbit. After enucleation orbital recurrence developed within 14 days. No anti-tumor treatment was given and the child died at the age of 4 weeks. The histopathological and cytogenetical analysis of the tumor is presented. The tumor was diagnosed as a retinoblastoma but we could not exclude the possibility of a neuroblastoma.

Published
1994
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3. A case of congenital form of retinoblastoma with D-deletion syndrome.

Author

Januszkiewicz D

Subjects
Carboxylic Ester Hydrolases genetics, Carboxylic Ester Hydrolases metabolism, Eye Neoplasms genetics, Eye Neoplasms therapy, Humans, Infant, Newborn, Male, Retinoblastoma genetics, Retinoblastoma therapy, Syndrome, Carboxylesterase, Chromosome Deletion, Chromosomes, Human, Pair 13, Eye Neoplasms congenital, Retinoblastoma congenital
Published
1991

4. Failure to thrive leading to early detection of retinoblastoma.

Author

Kingston JE, Clark J, Santos H, Jones D, and Hungerford JL

Subjects
Carboxylic Ester Hydrolases deficiency, Carboxylic Ester Hydrolases genetics, Eye Neoplasms congenital, Eye Neoplasms genetics, Eye Neoplasms therapy, Failure to Thrive diagnosis, Female, Humans, Infant, Infant, Newborn, Intellectual Disability genetics, Male, Muscle Hypotonia genetics, Neoplasms, Multiple Primary congenital, Neoplasms, Multiple Primary genetics, Retinoblastoma congenital, Retinoblastoma genetics, Retinoblastoma therapy, Syndrome, Carboxylesterase, Chromosome Deletion, Chromosomes, Human, Pair 13 ultrastructure, Eye Neoplasms diagnosis, Face abnormalities, Failure to Thrive genetics, Retinoblastoma diagnosis
Published
1990
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5. ["Umbrella syndrome," a contribution to pseudoretinoblastoma].

Author

Lommatzsch PK

Subjects
Child, Child, Preschool, Eye Neoplasms pathology, Female, Fluorescein Angiography, Humans, Hyperplasia, Male, Retinal Vessels pathology, Retinoblastoma pathology, Syndrome, Ultrasonography, Vitreous Body pathology, Eye Neoplasms congenital, Retinoblastoma congenital
Abstract

In two children referred to the author's clinic because of suspected retinoblastoma, pathologic fibroglial tissue was observed unilaterally in front of the macula and optic disk. Fluorescein angiography and ultrasonography indicated a posterior PHPV. In view of the morphological appearance the condition was termed "umbrella syndrome". There were no therapeutic consequences.

Published
1987
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6. Congenital retinoblastoma: a case report.

Author

Plotsky D, Quinn G, Eagle R Jr, Shields J, and Granowetter L

Subjects
Combined Modality Therapy, Eye Neoplasms diagnosis, Eye Neoplasms therapy, Humans, Infant, Newborn, Male, Neoplasm Recurrence, Local, Retinoblastoma diagnosis, Retinoblastoma therapy, Eye Neoplasms congenital, Retinoblastoma congenital
Abstract

Retinoblastoma is usually diagnosed during the first three years of life, with an average age of diagnosis of 18 months. It is almost never found at birth except when there is a positive family history which prompts an early fundus examination. We report a case of unilateral nonfamilial retinoblastoma which was so advanced at birth that it had already produced a perforated globe. Despite enucleation, radiation, and chemotherapy, massive orbital recurrence developed which necessitated a modified orbital exenteration. In spite of this aggressive therapy the child died of metastatic retinoblastoma at age eight months.

Published
1987
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