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Dynamic behavior and failure mechanism of slope during earthquake are hot topics in geotechnical engineering community. In Tianshui area, Northwest of China, the deformation features of loess-mudstone slopes induced by earthquakes are still not well understood. The current study aims to discuss the dynamic behavior of the slope under earthquake, by performing a series of centrifuge shaking table tests and numerical simulations. The results are processed for PGA amplificatory effect study and to evaluate the earthquake induced deformation mechanism. Better agreement is obtained between the results of numerical simulations and centrifuge tests. The results indicated that the acceleration response of the loess-mudstone slope showed several amplifying characteristic: the height effect, lithologic effect and surface effect. It also proves that the displacements in the loess layer are much larger than mudstone. As the input amplitude increased, the shear plastic zone developed along a further slide surface. Tension plastic zone mainly occurred at the crest. Roughly, the regions of earthquake induced deformation state increased with the increase in amplitude of earthquake wave. Deformations occurred at the upper part of the slope. Tensile cracks evolved on the crest and the upper part of slope in loess layer, moreover, failures occurred at slope surface, and only slight deformation at slope toe. Deformations with continuous shear cracks and slope surface upheavals developed at the middle part of slope. [ABSTRACT FROM AUTHOR]