1. The Effect of an Innovative Combination of Bergamot Polyphenolic Fraction and Cynara cardunculus L. Extract on Weight Gain Reduction and Fat Browning in Obese Mice.
- Author
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Nucera, Saverio, Scarano, Federica, Macrì, Roberta, Mollace, Rocco, Gliozzi, Micaela, Carresi, Cristina, Ruga, Stefano, Serra, Maria, Tavernese, Annamaria, Caminiti, Rosamaria, Coppoletta, Annarita, Cardamone, Antonio, Montalcini, Tiziana, Pujia, Arturo, Palma, Ernesto, Muscoli, Carolina, Barillà, Francesco, Musolino, Vincenzo, and Mollace, Vincenzo
- Subjects
WEIGHT loss ,WEIGHT gain ,CARDOON ,BROWN adipose tissue ,OXIDANT status ,FAT - Abstract
Obesity is one of the world's most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucial strategy for improving WAT inflammation and obesity and accelerating the browning process. The aim of this study was to perform a preclinical "proof of concept" study on Bergacyn
® , an innovative formulation originating from a combination of bergamot polyphenolic fraction (BPF) and Cynara cardunculus (CyC), for the treatment of adipose tissue dysfunction. In particular, Bergacyn® supplementation in WD/SW-fed mice at doses of 50 mg/kg given orally for 12 weeks, was able to reduce body weight and total fat mass in the WD/SW mice, in association with an improvement in plasma biochemical parameters, including glycemia, total cholesterol, and LDL levels. In addition, a significant reduction in serum ALT levels was highlighted. The decreased WAT levels corresponded to an increased weight of BAT tissue, which was associated with a downregulation of PPARγ as compared to the vehicle group. Bergacyn® was able to restore PPARγ levels and prevent NF-kB overexpression in the WAT of mice fed a WD/SW diet, suggesting an improved oxidative metabolism and inflammatory status. These results were associated with a significant potentiation of the total antioxidant status in WD/SW mice. Finally, our data show, for the first time, that Bergacyn® supplementation may be a valuable approach to counteract adipose tissue dysfunction and obesity-associated effects on cardiometabolic risk. [ABSTRACT FROM AUTHOR]- Published
- 2024
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