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Start Over Author "M. Pelsers" Topic fatty acid-binding proteins
4 results on '"M. Pelsers"'

1. FABP3 and FABP10 in Atlantic salmon (Salmo salar L.)--general effects of dietary fatty acid composition and life cycle variations.

Author

Jordal AE, Hordvik I, Pelsers M, Bernlohr DA, and Torstensen BE

Subjects
Amino Acid Sequence, Animals, Base Sequence, Fatty Acid-Binding Proteins genetics, Fatty Acids, Monounsaturated, Fish Proteins genetics, Liver metabolism, Molecular Sequence Data, Myocardium metabolism, Oxidation-Reduction, Plant Oils metabolism, RNA, Messenger metabolism, Rapeseed Oil, Time Factors, Dietary Fats metabolism, Fatty Acid-Binding Proteins metabolism, Fish Proteins metabolism, Life Cycle Stages physiology, Salmo salar growth & development
Abstract

The increased use of dietary plant oil supplementation combined with high dietary lipid loads challenges the lipid transport systems of cultivated fish species. Fatty acid binding proteins (FABPs) have been thoroughly studied as intracellular fatty acid transporters in vertebrates, but no data have been reported in Atlantic salmon. In the present study, comparative characterizations were performed, and dietary influence of plant oil supplementation on FABP3 and FABP10 expression was studied for several tissues in two separate dietary trials. In trial I, groups (6 fish each) were fed diets for 42 weeks (body mass 142+/-1 to 1463+/-83 g) (mean+/-S.D.), containing graded levels of rapeseed oil substituting for fish oil using a linear regression design. In trial II, groups (3 fish each) were fed 100% fish oil or 100% plant oil for 22 months (0.160+/-0.052 to 2523+/-590 g) (mean+/-S.D.) and sampled at regular intervals. Liver and muscle tissues appeared to express several FABPs possibly linked to different metabolic functions. FABPs mRNA expression did not change with dietary inclusion of 75% rapeseed oil, whereas FABP3 protein expression seemed to be affected by dietary rapeseed oil inclusion. Significant changes in red muscle FABP3 mRNA expression correlate to significant changes in total beta-oxidation capacity during the energy consuming process of smoltification.

Published
2006
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2. Monoclonal antibodies to human heart fatty acid-binding protein

Author

Jan F. C. Glatz, M. Symannek, E. Eymann, W. Roos, J. Duppenthaler, K. W. H. Wodzig, and M. Pelsers

Subjects
medicine.drug_class, Immunology, Enzyme-Linked Immunosorbent Assay, Nerve Tissue Proteins, Biosensing Techniques, Fatty Acid-Binding Proteins, Monoclonal antibody, Fatty acid-binding protein, Epitope, Epitopes, Mice, medicine, Animals, Humans, Immunology and Allergy, Bovine serum albumin, Mice, Inbred BALB C, biology, Chemistry, Myocardium, Tumor Suppressor Proteins, Binding protein, Fatty Acids, Antibodies, Monoclonal, Human heart, Molecular biology, Neoplasm Proteins, Biochemistry, Heart-type fatty acid binding protein, biology.protein, lipids (amino acids, peptides, and proteins), Antibody, Carrier Proteins, Fatty Acid-Binding Protein 7
Abstract

Heart-type fatty acid-binding protein (H-FABP), a 15 kDa non-enzymatic protein, which is abundantly present in heart and some skeletal muscles, was recently found to be a useful plasma marker for acute myocardial infarction. The BIAcore biosensor technology was used to raise and characterize a panel of 13 monoclonal antibodies against human H-FABP which did not crossreact with other FABP types of human origin. The kinetics of association and dissociation between FABP and the monoclonal antibodies was studied. By pairwise mapping several distinct epitopes could be identified.

Published
1995
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3. Multicenter evaluation of an amperometric immunosensor for plasma fatty acid-binding protein: an early marker for acute myocardial infarction

Author

G, Key, A, Schreiber, R, Feldbrügge, C J, McNeil, P, Jørgensen, M M, Pelsers, J F, Glatz, and F, Spencer

Subjects
Tumor Suppressor Proteins, Myocardial Infarction, Reproducibility of Results, Enzyme-Linked Immunosorbent Assay, Biosensing Techniques, Reference Standards, Fatty Acid-Binding Proteins, Myelin P2 Protein, Sensitivity and Specificity, Neoplasm Proteins, Evaluation Studies as Topic, Electrochemistry, Humans, Carrier Proteins, Fatty Acid-Binding Protein 7, Biomarkers
Published
1999

4. Influence of age and sex and day-to-day and within-day biological variation on plasma concentrations of fatty acid-binding protein and myoglobin in healthy subjects

Author

M M, Pelsers, J P, Chapelle, M, Knapen, C, Vermeer, A M, Muijtjens, W T, Hermens, and J F, Glatz

Subjects
Adult, Male, Myoglobin, Tumor Suppressor Proteins, Age Factors, Middle Aged, Fatty Acid-Binding Proteins, Myelin P2 Protein, Neoplasm Proteins, Sex Factors, Reference Values, Humans, Female, Carrier Proteins, Fatty Acid-Binding Protein 7, Aged
Published
1999

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