1. Non-esterified fatty acids impair insulin-mediated glucose uptake and disposition in the liver.
- Author
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Iozzo P, Lautamaki R, Geisler F, Virtanen KA, Oikonen V, Haaparanta M, Yki-Jarvinen H, Ferrannini E, Knuuti J, and Nuutila P
- Subjects
- Adult, Biological Transport, Humans, Kinetics, Male, Phosphorylation, Positron-Emission Tomography, Radiopharmaceuticals pharmacokinetics, Reference Values, Fatty Acids, Nonesterified blood, Fluorodeoxyglucose F18 pharmacokinetics, Glucose metabolism, Insulin physiology, Liver metabolism
- Abstract
Aims/hypothesis: We investigated the effect of elevated circulating NEFA on insulin-mediated hepatic glucose uptake (HGU) and whole-body glucose disposal (M) in eight healthy male subjects., Methods: Studies were performed using positron emission tomography (PET) and [(18)F]-2-fluoro-2-deoxyglucose ([(18)F]FDG) during euglycaemic hyperinsulinaemia (0-120 min) and an Intralipid/heparin infusion (IL/Hep; -90-120 min). On a different day, similar measurements were taken during euglycaemic hyperinsulinaemia and saline infusion (SAL). Graphical and compartmental analyses were used to model liver data., Results: Circulating NEFA increased approximately three-fold during IL/Hep, and declined by 81+/-7% in the SAL study ( p
- Published
- 2004
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