1. Reduced Exercise Capacity, Chronotropic Incompetence, and Early Systemic Inflammation in Cardiopulmonary Phenotype Long Coronavirus Disease 2019
- Author
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Durstenfeld, Matthew S, Peluso, Michael J, Kaveti, Punita, Hill, Christopher, Li, Danny, Sander, Erica, Swaminathan, Shreya, Arechiga, Victor M, Lu, Scott, Goldberg, Sarah A, Hoh, Rebecca, Chenna, Ahmed, Yee, Brandon C, Winslow, John W, Petropoulos, Christos J, Kelly, J Daniel, Glidden, David V, Henrich, Timothy J, Martin, Jeffrey N, Lee, Yoo Jin, Aras, Mandar A, Long, Carlin S, Grandis, Donald J, Deeks, Steven G, and Hsue, Priscilla Y
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Coronaviruses ,Clinical Research ,Physical Activity ,Heart Disease ,Infectious Diseases ,Cardiovascular ,Emerging Infectious Diseases ,Good Health and Well Being ,Female ,Male ,Humans ,Exercise Tolerance ,Contrast Media ,Heart Rate ,COVID-19 ,SARS-CoV-2 ,Gadolinium ,Inflammation ,Phenotype ,cardiac magnetic resonance imaging ,cardiopulmonary exercise testing ,chronotropic incompetence ,postacute sequelae of COVID-19 ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundMechanisms underlying persistent cardiopulmonary symptoms after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (postacute sequelae of coronavirus disease 2019 [COVID-19; PASC] or "long COVID") remain unclear. This study sought to elucidate mechanisms of cardiopulmonary symptoms and reduced exercise capacity.MethodsWe conducted cardiopulmonary exercise testing (CPET), cardiac magnetic resonance imaging (CMR) and ambulatory rhythm monitoring among adults >1 year after SARS-CoV-2 infection, compared those with and those without symptoms, and correlated findings with previously measured biomarkers.ResultsSixty participants (median age, 53 years; 42% female; 87% nonhospitalized; median 17.6 months after infection) were studied. At CPET, 18/37 (49%) with symptoms had reduced exercise capacity (1 year after COVID-19 were associated with reduced exercise capacity, which was associated with earlier inflammatory markers. Chronotropic incompetence may explain exercise intolerance among some with "long COVID."
- Published
- 2023