1. Controversies in the therapeutic approach to congenital cytomegalovirus infection
- Author
-
Juan Arnaez, Maria Garrido-Barbero, and Alfredo García-Alix
- Subjects
0301 basic medicine ,Microbiology (medical) ,Male ,Pediatrics ,medicine.medical_specialty ,030106 microbiology ,Cytomegalovirus ,Antiviral Agents ,03 medical and health sciences ,Therapeutic approach ,0302 clinical medicine ,Cerebrospinal fluid ,medicine ,Humans ,Valganciclovir ,030212 general & internal medicine ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Brain ,Infant ,Magnetic resonance imaging ,General Medicine ,Magnetic Resonance Imaging ,Infectious Diseases ,Spain ,Cytomegalovirus Infections ,Female ,business ,beta 2-Microglobulin - Abstract
Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection admitted to our neonatal unit between 2015 and 2019, half showed paucisymptomatic neurological manifestations. In these cases, the determination of s2-microglobulin in cerebrospinal fluid and magnetic resonance imaging aided in the decision-making concerning the therapeutic approach to follow.
- Published
- 2019