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Assessment of viable myocardium in territories of hypoperfused myocardium is important for predicting functional recovery after revascularization. This study was designed to evaluate quantitative analysis of 99mTc-labeled 2-methoxyisobutyl isonitrile (MIBI) myocardial perfusion imaging combined with isosorbide dinitrate (ISDN) infusion to detect myocardial viability in patients with chronic coronary artery disease before and after revascularization.Twenty-seven consecutive patients with previous myocardial infarction and left ventricular dysfunction (left ventricular ejection fraction 35.2% +/- 13.5%) referred for coronary artery bypass (CABG) were studied with 99mTc-labeled MIBI single-photon emission computed tomography at rest and during ISDN infusion before CABG followed by resting imaging after CABG. Quantitative analysis was performed with circumferential profiles. Left ventricular function (global and regional) was assessed by radionuclide ventriculography before and after CABG. Out of 212 abnormal perfusion segments with resting 99mTc-labeled MIBI SPECT, 99 segments (47%) showed improved uptake of 99mTc-labeled MIBI during ISDN infusion. The mean ratio of myocardial uptake was 0.58 +/- 0.25 (resting 0.53 +/- 0.23; p0.05). After CABG, of 212 segments with hypoperfusion, 108 segments (51%; p0.05 vs ISDN) showed improved uptake of 99mTc-labeled MIBI. The mean ratio of myocardial uptake was 0.60 +/- 0.26 (resting 0.53 +/- 0.23; p0.05). The concordance between the improvement of post-CABG wall motion and that of pre-CABG ISDN perfusion imaging was 83%, between the improvement of wall motion and perfusion imaging after CABG 94%, and between the improvement of pre-CABG ISDN and post-CABG perfusion imaging 83%, respectively.ISDN infusion can improve the uptake of 99mTc-labeled MIBI in hypoperfused myocardium and increase the efficiency of 99mTc-labeled MIBI in the detection of viable myocardium in patients with previous myocardial infarction and left ventricular dysfunction.

According to the therapeutic principles, reinforcing Kidney-Qi and nourishing the blood were used in treating renal anemia, Renal Anemia Granule No. I and No. II (RAG I and II) were applied in treating patients of renal anemia, the former was a Yin reinforcing agent and the latter a Yang tonics principally. Thirty patients were treated according to the Syndrome Differentiation of TCM and divided into two groups: (1) The combined group, oral liquid of the whole embryo extract was given additionally. (2) The discombined group, no additional drug was given. Patients after treatment all showed significant improvements in serum erythropoietin and hemoglobin (P0.05). Experimental study in animal models also displayed the hemoglobin of treated group increased more than that of control group (P0.05), which might be related to the enhancement of hematopoietic function of bone marrow.