1. A Double-Blind, Placebo-Controlled Study Comparing the Effects of Sertraline Versus Amitriptyline in the Treatment of Major Depression
- Author
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R B Lydiard, Stephen M. Stahl, M Hertzman, and Wilma Harrison
- Subjects
Adult ,Male ,medicine.medical_specialty ,Patient Dropouts ,medicine.drug_class ,Amitriptyline ,Placebo-controlled study ,Tricyclic antidepressant ,Antidepressive Agents, Tricyclic ,Placebo ,Profile of mood states ,Drug Administration Schedule ,Placebos ,Double-Blind Method ,Sertraline ,Internal medicine ,Ambulatory Care ,medicine ,Health Status Indicators ,Humans ,Psychiatry ,Psychiatric Status Rating Scales ,Depressive Disorder ,Beck Depression Inventory ,Hamilton Rating Scale for Depression ,Psychiatry and Mental health ,1-Naphthylamine ,Treatment Outcome ,Quality of Life ,Patient Compliance ,Female ,Psychology ,Selective Serotonin Reuptake Inhibitors ,medicine.drug - Abstract
Background: This study was designed to compare the efficacy, safety, tolerability profiles, and effects on quality of life of the serotonin selective reuptake inhibitor antidepressant sertraline versus the nonselective tricyclic antidepressant amitriptyline and placebo in patients with major depression. Method: Outpatients with DSM-III-R major depression were randomly assigned to double-blind treatment for 8 weeks with sertraline (50-200 mg daily), amitriptyline (50-150 mg daily), or matching placebo. Assessments included the Hamilton Rating Scale for Depression, Montgomery-Asberg Depression Rating Scale, Clinical Global Impressions-Severity of Illness scale, Clinical Global Impressions-Improvement scale, Global Assessment Scale, Profile of Mood States, Beck Depression Inventory, Quality of Life Enjoyment and Satisfaction Questionnaire, and Health-Related Quality of Life battery. Results: All treatment groups demonstrated statistically significant improvement from baseline in depression ratings by Week I and thereafter. The antidepressant effects of amitriptyline and sertraline were significantly (p more...
- Published
- 1997
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