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The aim of this study was to ascertain the accuracy of phase angle (PhA) as a predictor of mortality during intensive care unit (ICU) stay (MPatients aged60 y who were under mechanical ventilation (MV) ≥48 h were included once they were hemodynamically stable. PhA was measured by single-frequency bioelectrical impedance analysis up to 48 h after admission. ICU prognostic scores, functional scale, and nutritional assessments were performed in the first 24 h. Patients were followed for 60 d after ICU admission.We enrolled 102 patients into the present study. PhA was significantly higher (P0.001) in survivors at MLow PhA values are associated with higher late mortality and a short survival time at 60 d in critically ill older adults. Low PhA values can be considered a useful ICU prognostic score in similar populations.

AIM To evaluate the Probability of Repeated Admission (Pra) scale performance in predicting healthcare utilization and death in a community sample of Rio de Janeiro city, Brazil. METHODS This was a prospective longitudinal study. The sample was composed of community-dwelling older people who participated in the research network Frailty in Brazilian Older People Study, Rio de Janeiro section. It analyzed data from the baseline and the follow up. At the baseline, 764 older adults were stratified by the Pra, and, 3 years later, data on health services utilization and survival status were collected. The Pra accuracy, obtained by the area under the curve, the sensitivity and the specificity to predict hospitalization in 3 years; visits to the emergency department; and death were determined. Cox regression estimated the survival curves, according to the risk strata. RESULTS The accuracy, the sensitivity and the specificity of Pra were 62% (95% CI 57-68%), 8.8% and 95.4% for hospitalization in 3 years; 59% (95% CI 53-64%), 8.3% and 94.8% for emergency room visits; 66% (95% CI 59-74%) and 68% (95% CI 63-73%), 15.0% and 96.0% for death. Survival curves showed that high-risk individuals were more likely to die compared with the low-risk individuals, adjusted to covariables (P

Background Handgrip strength (HGS) is an indicator of muscle strength, suited for evaluating the aging process. Its use depends on the availability of reliable normative reference values (NRV). The main objective of this study is to provide NRV of HGS for Brazilians aged 65 to 90 years. Methods Participants were from the Frailty in Brazilian Older People research. 2,999 successful aging (SA) participants comprised the development sample. HGS was measured using a hydraulic dynamometer. Obtaining NRV involved regressing HGS on age per sex-height strata, fitting separate fractional polynomial (FP) models for the mean and coefficient of variation. Model fit was assessed via standardized residuals, probability/quantile plots, and comparing observed to normal expected percentages of participants falling within specified centile intervals. For validation, the latter procedure was applied to 2,369 unsuccessfully aging (UA) participants. Results Across strata, the best-fitting models for the means were FP of power 1. FP models for the CV indicated age invariance, entailing steady heteroscedastic age decline in SD since coefficients for the means were negative and SD = CV×mean. All models adjusted well. Centiles distributions for the SA and UA populations showed anticipated patterns, respectively falling on and below the normative expected centile references. Results (NRV) are presented in tables and centile charts. Equations are also provided. Conclusion NRV/charts may be endorsed for routine use, while still tested further. They would aid professionals caring for older people, not only to identify those at risk and eligible for immediate provisions, but also in planning prevention and rehabilitation measures.

Background Leprosy continues to be a public health problem in Brazil. Furthermore, detection rates in elderly people have increased, particularly those of multibacillary (L-Lep) patients, who are responsible for transmitting M. leprae. Part of the decline in physiological function during aging is due to increased oxidative damage and change in T cell subpopulations, which are critical in defense against the disease. It is not still clear how age-related changes like those related to oxidation affect elderly people with leprosy. The aim of this work was to verify whether the elderly leprosy patients have higher ROS production and how it can impact the evolution of leprosy. Methodology/Principal findings 87 leprosy patients, grouped according to age range and clinical form of leprosy, and 25 healthy volunteers were analyzed. Gene expression analysis of antioxidant and oxidative burst enzymes were performed in whole blood using Biomark’s microfluidic-based qPCR. The same genes were evaluated in skin lesion samples by RT-qPCR. The presence of oxidative damage markers (carbonylated proteins and 4-hydroxynonenal) was analyzed by a DNPH colorimetric assay and immunofluorescence. Carbonylated protein content was significantly higher in elderly compared to young patients. One year after multidrug therapy (MDT) discharge and M. leprae clearance, oxidative damage increased in young L-Lep patients but not in elderly ones. Both elderly T and L-Lep patients present higher 4-HNE in cutaneous lesions than the young, mainly surrounding memory CD8+ T cells. Furthermore, young L-Lep demonstrated greater ability to neutralize ROS compared to elderly L-Lep patients, who presented lower gene expression of antioxidant enzymes, mainly glutathione peroxidase. Conclusions/Significance We conclude that elderly patients present exacerbated oxidative damage both in blood and in skin lesions and that age-related changes can be an important factor in leprosy immunopathogenesis. Ultimately, elderly patients could benefit from co-supplementation of antioxidants concomitant to MDT, to avoid worsening of the disease., Author summary Leprosy, which has been reported throughout human history since Biblical times, still presents unclear aspects in regards to its pathogeny, and represents a public health concern, particularly in developing countries, where poor sanitary conditions of socially disfavored groups is a relevant contributing factor in maintaining disease dissemination. Although its signs and symptoms are primarily found in young adults, the increasing number of elderly individuals with leprosy is a recent phenomenon that requires clarification. Considering the specific biochemical profile of the elderly, as well as the influence thereof on their immune response to infection, this work demonstrates that elderly leprosy patients present increased levels of oxidative damage in blood and skin lesions when compared to younger patients. Such findings appear to be correlated with low gene expression of antioxidant enzymes, particularly among multibacillary patients. This work intends to contribute to a better understanding on the progress of leprosy in elderly groups.

Leprosy is an infectious disease that remains endemic in approximately 100 developing countries, where about 200,000 new cases are diagnosed each year. Moreover, multibacillary leprosy, the most contagious form of the disease, has been detected at continuously higher rates among Brazilian elderly people. Due to the so-called immunosenescence, characterized by several alterations in the quality of the immune response during aging, this group is more susceptible to infectious diseases. In view of such data, the purpose of our work was to investigate if age-related alterations in the immune response could influence the pathogenesis of leprosy. As such, we studied 87 individuals, 62 newly diagnosed and untreated leprosy patients distributed according to the age range and to the clinical forms of the disease and 25 healthy volunteers, who were studied as controls. The frequency of senescent and memory CD8+ leukocytes was assessed by immunofluorescence of biopsies from cutaneous lesions, while the serum levels of IgG anti-CMV antibodies were analyzed by chemiluminescence and the gene expression of T cell receptors' inhibitors by RT-qPCR. We noted an accumulation of memory CD8+ T lymphocytes, as well as reduced CD8+CD28+ cell expression in skin lesions from elderly patients, when compared to younger people. Alterations in LAG3 and PDCD1 gene expression in cutaneous lesions of young MB patients were also observed, when compared to elderly patients. Such data suggest that the age-related alterations of T lymphocyte subsets can facilitate the onset of leprosy in elderly patients, not to mention other chronic inflammatory diseases.

OBJECTIVES: To assess the prevalence of sarcopenic obesity and its association with functionality, lifestyle, biomarkers, and morbidities in older adults. METHODS: The study analyzed cross-sectional data from 270 older adults who participated in phase III of the Frailty in Brazilian Older People Study (Fragilidade em Idosos Brasileiros—Rio de Janeiro, FIBRA-RJ study-2013). They took part in a home interview surveying socioeconomic, demographic, lifestyle, morbidities, and functional data. Blood was collected for biochemical marker analysis and participants’ body composition was determined by dual-energy X-ray absorptiometry. For women, the diagnosis of sarcopenic obesity was defined at a body fat percentage ≥38% and appendicular skeletal muscle mass index (ASMMI)

OBJECTIVE: To investigate the risk of mortality associated with sarcopenic obesity (SO), obesity (OB), and sarcopenia in elderlies. METHODS: We analyzed longitudinal data from 270 participants > 65 years of age of Phase III of the Study on Frailty in Brazilian Older People (FIBRA–RJ–2012). Socioeconomic, demographic, lifestyle, morbidity, and functional data were collected by home based interviews. DXA and body composition assessment was conducted in a laboratory. In women, OB was diagnosed when body fat percentage ≥ 38% and sarcopenia by an Appendicular Lean Mass Index (ALMI) < 6.00 kg/m² and muscle strength < 16 Kgf. In men, OB was diagnosed when body fat percentage ≥ 27%, and sarcopenia was diagnosed with ALMI < 7.00 kg/m² and muscle strength < 27 Kgf. SO was assessed by combining variables used to diagnose obesity and sarcopenia. The probabilistic linkage method was used to obtain deaths in the 2012-January 2017 period from the Brazilian Mortality Registry. Cox regression models were tested, and crude and adjusted hazard ratio calculations were conducted. RESULTS: After adjusting for sex, age, race/skin color, walking as an exercise, and hypertension, individuals with sarcopenia were 5.7 times more likely to die (95%CI: 1.17–27.99) than others without sarcopenia and obesity. CONCLUSION: A high risk of death was observed in individuals with sarcopenia. These results show the need for preventive strategies of early detection and treatment in order to increase survival employing multimodal interventions.

This article aims to categorize elderly non-frail (NF), pre-frail (PF) and frail (FF) as to fast and slow gait speed. Compare NF, PF and FF, and analyze associations between fast or slow gait speed with clinical, functional and mental factors. 5,501 elderly (65 years or over; to the Frailty in Brazilian Older People Study), classified as NF, PF and FF (Fried´s frailty phenotype) and, in relation to fast gait speed (≥ 0.8m/s) and slow (< 0.8m/s). Age, sex, body mass index, muscular strength, advanced, instrumental and basic activities of daily living, falls, fear of falling and depressive symptoms were evaluated. Logistic regression analysis investigated associations between variables. The proportion of the slow elderly increased with fragility (NF = 12.39%, PF = 37.56%, FF = 88.83%, p < 0.01). Be woman, performance in activities of daily living, muscle strength and fall were associated with fragility syndrome. The association between frailty and adverse health outcomes reinforces its primacy as an indicator of the functional health of the elderly. Functional capacity, muscular strength, and falls should be evaluated considering their potential for reversibility. Resumo O artigo tem por objetivos categorizar idosos não frágeis (NF), pré-frágeis (PF) e frágeis (FF) quanto à velocidade rápida e lenta de marcha. Compara NF, PF e FF, e analisa associações entre velocidade de marcha rápida e lenta com fatores clínicos, funcionais e mentais. 5.501 idosos (65 anos ou mais; Estudo de Fragilidade em Idosos Brasileiros - Rede Fibra), classificados em NF, PF e FF (fenótipo de fragilidade de Fried) e, quanto a velocidade de marcha rápida (≥ 0.8m/s) e lenta (< 0.8m/s). Avaliou-se idade, sexo, índice de massa corpórea, força muscular, atividades instrumentais, básicas e avançadas de vida diária, quedas, medo de quedas e sintomas depressivos. Análise de regressão logística para verificar associação entre variáveis. A proporção de idosos lentos aumentou com a fragilidade (NF = 12,39%, PF = 37,56%, FF = 88,83%, p < 0,01). Ser mulher, desempenho nas atividades de vida diária, força muscular e relato de quedas associou-se com a fragilidade. A associação entre fragilidade e eventos adversos de saúde reforçou sua importância em ser um indicador da saúde funcional dos idosos. Capacidade funcional, força muscular e ocorrência de quedas devem ser avaliados, considerando seu potencial de reversibilidade.

Background/ Objectives The multiple dietary restrictions recommended to hemodialysis (HD) patients, coupled with conditions imposed from aging may lead to a poor dietary quality in these patients. This study investigated the dietary quality and the consumption of ultra-processed food of elderly patients on HD and non-chronic kidney disease (CKD) elderly. Additionally, the diet on the dialysis day and non-dialysis days was evaluated. Subjects/ Methods Cross-sectional study conducted with 153 non-institutionalized elderly patients on HD (Elder-HD) and 47 non-CKD elderly (Elder-Healthy) aged ≥ 60 years. From a 3-day food records, the dietary quality was assessed by using the Brazilian Healthy Eating Index Revised (BHEI-R) and the energy contribution of food processing groups. Results Compared with the Elder-Healthy group, the Elder-HD group showed a lower total BHEI-R score (P

This article aims to investigate whether difficulty in taking medication is associated with stroke among older adults with Systemic Arterial Hypertension (SAH) and to explore their association with living arrangements. Cross-sectional study was based on 3,502 older adults with SAH from the four universities pole of Frailty in Brazilian Older People (Fibra) Study, Brazil, including 14 municipalities of the five Brazilian regions. We used the medical diagnosis of stroke and difficulty in taking medications (self-reported difficulty and financial difficulty affording prescribed medications). Multivariate analysis was performed using logistic regression. Differently from women, older men with SAH, which report difficulty in taking medication (unintentional non-adherence), have higher odds of stroke. When stratified by living arrangements, those living with a partner have even higher odds of stroke compared to those without difficulty in taking medication and living alone. None association was found for difficulty affording prescribed medication for both men and women. Unintentional difficulty in taking medication plays a role in SAH treatment among men. Primary care strategies for controlling blood pressure should not be focus only on patients but targeting spouses as well. Resumo O objetivo deste artigo é investigar se a dificuldade em tomar medicamentos está associada ao acidente vascular encefálico (AVE) entre idosos com hipertensão arterial sistêmica (HAS) e explorar esta associação com arranjos familiares. Estudo seccional baseado em 3.502 idosos com HAS dos quatro polos do Estudo Fibra, Brasil, incluindo 14 cidades das cinco regiões brasileiras. Foi usado o diagnóstico médico de AVE e a dificuldade em tomar medicamentos (dificuldade autorrelatada e dificuldade financeira). Utilizou-se a regressão logística na análise multivariada. Diferentemente das mulheres, homens com HAS que relataram dificuldade em tomar medicamentos (não adesão não intencional) apresentam maior chance de ter AVE. Quando estratificado por arranjos familiares, homens que moravam com o cônjuge apresentaram chance ainda maior de ter AVE, quando comparados com aqueles sem dificuldade em tomar medicamentos e que vivem sozinhos. Nenhuma associação foi encontrada para dificuldade financeira, tanto para mulheres quanto para homens. Dificuldades não intencionais em tomar medicamentos têm um papel importante no controle da HAS entre homens. Estratégias de controle da pressão arterial realizadas na atenção primária não devem focar apenas nos pacientes, mas nos cônjuges destes pacientes.

OBJECTIVE: To evaluate the incidence and persistence of fear of falling in older adults and the clinical/functional, psychosocial and lifestyle-related risk factors. METHODS: A longitudinal study with 393 community-dwelling older adults aged 65 years and over (110 men/ 283 women) resident in the North Zone of the city of Rio de Janeiro, Brazil. The fear of falling was assessed by the Falls Efficacy Scale-I-BR. The explanatory variables assessed were: number of comorbidities and medicines, history of falls, fracture from falling, use of walking aids, functional dependence in basic and instrumental activities of daily living, hearing and visual impairment, hand grip strength, walking speed, self-rated health, body mass index, depressive symptoms, cognitive impairment, living alone and activity level. Incidence, persistence and risk factors were estimated. Multivariate analysis was performed using Poisson Regression, obtaining relative risks (RR) and corresponding to 95% confidence intervals. RESULTS: Among the 393 participants, fear of falling occurred in 33.5% and was persistent in 71.3%. Incidence was found to associate with using seven or more medicines and reporting worse activity level than the prior year. Risk factors for persistent fear were: using seven or more medicines, a history of one or two falls, reduced walking speed, hearing impairment, cognitive impairment, depressive symptoms and poor or very poor self-rated health. CONCLUSION: Fear of falling is a frequent and persistent condition. Many factors related to persistent fear showed no association with the incidence of fear, emphasizing the need for focused strategies to reduce risk factors that may be associated with the chronification of fear of falling.

OBJECTIVES: Sarcopenia is a common treatable geriatric condition. The aim of this study was to estimate the prevalence of sarcopenia and its associated factors in community-dwelling elderly living in Rio de Janeiro, Brazil, and to discuss the impact of different muscle mass, handgrip strength and gait speed cut-off values on the reported frequency of sarcopenia. METHODS: The health habits, functional capacity, and anthropometric measurements of 745 individuals aged ≥65 years from the Frailty in Brazilian Older People study were analyzed. The participants were classified into the following four groups: no sarcopenia, pre-sarcopenia, sarcopenia and severe sarcopenia. Univariate and multivariate regression analyses were performed. Muscle mass, handgrip strength and gait speed cut-off thresholds tailored to the sample and those proposed by the European Working Group on Sarcopenia in Older People were used to compare the prevalence rates of sarcopenia. RESULTS: Seventy-three percent of the participants were female, 61.9% were Caucasian, and the mean age was 76.6 years. The prevalence rates of sarcopenia were 10.8% and 18% using the sample-tailored and European consensus cut-off values, respectively. Sarcopenia was associated with advanced age (OR: 37.2; CI95%12.35-112.48), Caucasian race (OR: 1.89; CI 95% 1.02-3.52), single marital status (OR:6; CI95% 2.2-16.39), low income (OR:3.64; CI 95% 1.58-8.39), and the presence of comorbidities (OR:3.26; CI 95%1.28-8.3). CONCLUSION: In this study, the estimated prevalence of sarcopenia was similar to that reported in most studies after the tailored handgrip strength and gait speed cut-off values were adopted. A higher prevalence was observed when the cut-off values suggested by the European consensus were used. This indicates that the prevalence of sarcopenia must be estimated using population-specific reference values.

We examined whether women who had regular jobs throughout life performed better cognitively than older adult housewives. Linear regression was used to compare global cognitive performance scores of housewives (G1) and women exposed to work of low (G2) and high (G3) complexity. The sample comprised 477 older adult Brazilian women, 430 (90.4%) of whom had performed lifelong jobs. In work with data, the G2 group's cognitive performance scores were 1.73 points higher (p =.03), and the G3 group scored 1.76 points (p =.02) higher, than the G1. In work with things and with people, the G3 scored, respectively, 2.04 (p

Objective To investigate whether the dietary intake of elderly patients on hemodialysis (HD) is lower than that of elderly individuals with normal renal function. In addition, we also assessed whether the dietary intake of elderly on HD is lower on the dialysis day (DD) than on nondialysis days (non-DD). Design A cross-sectional and observational study including elderly on HD and non–chronic kidney disease (non-CKD) elderly. Subjects We assessed 54 noninstitutionalized elderly patients on HD (study group) and 47 non-CKD elderly (control group) aged ≥60 years. Main Outcome Measures All participants had their dietary intake assessed by 3-day food diaries. As a sensitivity analysis, we also assessed the dietary intake in the adequate reporters, which were identified when the ratio—energy intake-to-estimated basal metabolic rate—was above 1.27 (Goldberg index). Results When comparing dietary intake between the study and control groups, adjusted for sex and underreporting, it was noted that only the intake of protein (β: −9.9; P : .01) and phosphorus (β: −104; P : .04) were significantly lower in the study group. In addition, when furthering the analysis in the study group by comparing DD with non-DD, it was observed that energy (18 ± 7 vs. 21 ± 8 kcal/kg/day), protein (0.8 ± 0.4 vs. 1.0 ± 0.4 g/kg/day), lipids (41 ± 20 vs. 48 ± 23 g/day), potassium (1371 ± 587 vs. 1540 ± 484 mg/day), and phosphorous intake (647 ± 312 vs. 789 ± 287 mg/day), but not carbohydrate (155 ± 54 vs. 167 ± 55 g/day) and calcium (470 ± 345 vs. 518 ± 333 g/day) were significantly lower on DDs than on non-DDs, respectively. Conclusions Except for protein and phosphorous, energy and nutrient intake of elderly patients on HD are similar to that of non-CKD elderly. In addition, the dietary intake is lower on DDs, highlighting the importance of focusing efforts to improve nutritional intake mainly during the day of dialysis treatment.

This study aimed to assess the dimensional structure and internal consistency of the Brazilian version of the Functional Activities Questionnaire (FAQ-BR) for measurement of functional capacity in the elderly, based on the informant's report. This was a cross-sectional study with 525 non-institutionalized elderly informants, in which confirmatory factor analyses (CFA) and exploratory/confirmatory factor analyses (E/CFA) modeled according to CFA principles were used to identify the most parsimonious model and that with the best fit. The internal consistency of the FAQ-BR was assessed by composite reliability, and correlations between its dimensions were examined to investigate discriminant factor validity. CFA did not corroborate the unidimensional structure as originally proposed. Next, E/CFA fit a bidimensional structure that was reassessed by CFA, displaying a model without cross loads as the most parsimonious and with adequate fit indices. The internal consistency of FAQ-BR was considered satisfactory, and the correlation between its dimensions was acceptable. These findings are important, since they demonstrate the scale's capacity to capture the elderly's functional capacity construct in a different sociocultural context from that in which it was originally developed. The FAQ-BR can thus be considered an appropriate bidimensional instrument for measuring the elderly's functional capacity based on the informant's report, and its use in studies with similar populations is recommended.Este estudo teve por objetivo avaliar a estrutura dimensional e a consistência interna da versão brasileira do Functional Activities Questionnaire (FAQ-BR) para aferição da capacidade funcional do idoso, com base no relato de informante. Trata-se de um estudo seccional desenvolvido com 525 informantes de idosos não institucionalizados, em que análises fatoriais confirmatórias (AFC) e análises fatoriais exploratórias (AFC/E), modeladas segundo os princípios da AFC, foram usadas para identificar o modelo mais parcimonioso e mais bem ajustado. A consistência interna do FAQ-BR foi avaliada pela confiabilidade composta, e correlações entre suas dimensões foram examinadas a fim de investigar validade fatorial discriminante. A AFC não corroborou a estrutura unidimensional originalmente proposta. Em seguida, a AFC/E ajustou uma estrutura bidimensional que foi reavaliada por AFC, evidenciando um modelo sem cargas cruzadas como o mais parcimonioso e com adequados índices de ajuste. A consistência interna do FAQ-BR foi considerada satisfatória, e a correlação entre suas dimensões, aceitável. Esses achados são importantes, pois revelam a capacidade de a escala capturar o construto capacidade funcional do idoso em um contexto sociocultural distinto daquele em que foi desenvolvido. Portanto, o FAQ-BR pode ser considerado um instrumento bidimensional apropriado para aferir a capacidade funcional do idoso com base no relato do informante, e seu uso em pesquisas com populações semelhantes é recomendado.El objetivo de este artículo fue evaluar la estructura dimensional y la consistencia interna de la versión brasileña del Functional Activities Questionnaire (FAQ-BR) para la valoración de la capacidad funcional del anciano, en base al relato del informante. Se trata de un estudio seccional, desarrollado con 525 informantes de ancianos no institucionalizados, donde los análisis factoriales confirmatorios (AFC) y análisis factoriales exploratorios (AFC/E), fueron modelados según los principios de la AFC, así como usados para identificar el modelo más parsimonioso y más bien ajustado. La consistencia interna del FAQ-BR se evaluó por la fiabilidad compuesta, y se examinaron las correlaciones entre sus dimensiones, a fin de investigar la validez factorial discriminante. La AFC no corroboró la estructura unidimensional originalmente propuesta. En seguida, la AFC/E ajustó una estructura bidimensional que se reevaluó por parte de la AFC, evidenciando un modelo sin cargas cruzadas como el más parsimonioso y con adecuados índices de ajuste. La consistencia interna del FAQ-BR se consideró satisfactoria, y la correlación entre sus dimensiones, aceptable. Estos hallazgos son importantes, pues revelan la capacidad de la escala de aprehender el constructo capacidad funcional del anciano en un contexto sociocultural distinto de aquel en el que se desarrolló. Por ello, el FAQ-BR puede ser considerado un instrumento bidimensional, apropiado para evaluar la capacidad funcional anciano, basándose en el relato del informante, y se recomienda su uso en investigaciones con poblaciones semejantes.

Previous studies have indicated that dementia and depression have a considerable impact on the functional capacity of older adults, also influencing awareness about ability. The purpose of the current study was to investigate the impact of dementia, depression and awareness on activities of daily living (ADL) in a sample from a middle-income country.The current study explored impairments in basic, instrumental and advanced ADL using a factorial design comparing four groups: people with dementia and depression, people with dementia without depression, older adults with depression but no dementia and healthy older adults. For each type of ADL, self-report and informant report was contrasted in order to investigate the issue of lack of awareness in relation to ADL.Results indicate that dementia is associated with impairments in all types of ADL. Advanced ADL were also reduced in depressed participants. In addition, in the case of instrumental and basic ADL, informant report indicated less preserved abilities than participant self-report, particularly in people with dementia.The findings highlight the importance of developing interventions and compensatory strategies to prevent loss of ADL in dementia, also suggesting that early intervention in older adults with depression should focus on advanced ADL to prevent social isolation and withdrawal. Finally, the findings indicate that self-information about ADL may be compromised in dementia, so clinicians exploring disability should consider fully different aspects of ADL in this group. Copyright © 2017 John WileySons, Ltd.

Background: there is a lack of consensus on the diagnosis of sarcopenia. A screening and diagnostic algorithm was proposed by the European Working Group on Sarcopenia in Older People (EWGSOP). Objective: to assess the performance of the EWGSOP algorithm in determining the proportion of subjects suspected of having sarcopenia and selected to undergo subsequent muscle mass (MM) measurement. Design: a cross-sectional study. Setting: the cohorts, Frailty in Brazilian Older People Study—Rio de Janeiro (FIBRA-RJ), Brazil; Coyoacan Cohort (CC), Mexico City, Mexico; and Toledo Study for Healthy Aging (TSHA), Toledo, Spain. Subjects: three thousand two hundred and sixty community-dwelling individuals, 65 years and older. Methods: initially, the EWGSOP algorithm was applied using its originally proposed cut-off values for gait speed and handgrip strength; in the second step, values tailored for the specific cohorts were used. Results: using the originally suggested EWGSOP cut-off points, 83.4% of the total cohort (94.4% in TSHA, 75.5% in FIBRA-RJ, 67.8% in CC) would have been considered as suspected of sarcopenia. Adapted cut-off values lowered the proportion of abnormal results to 34.2% (quintile-based approach) and 23.71% (z-score approach). Conclusions: the algorithm proposed by the EWGSOP is of limited clinical utility in screening older adults for sarcopenia due to the high proportion of subjects selected to further undergo MM assessment. Tailoring cut-off values to specific characteristics of the population being studied reduces the number of people selected for MM assessment, probably improving the performance of the algorithm. Further research including the objective measure of MM is needed to determine the accuracy of these specific cut-off points.

Systolic hypertension is associated with cognitive decline in the elderly. Altered blood pressure (BP) variability is a possible mechanism of reduced cognitive performance in elderly hypertensives. We hypothesized that altered beat-to-beat systolic BP variability is associated with reduced global cognitive performance in elderly hypertensive subjects. In exploratory analyses, we also studied the correlation between diverse discrete cognitive domains and indices of systolic BP and heart rate variability. Disproving our initial hypothesis, we have shown that hypertension and low education, but not indices of systolic BP and heart rate variability, were independent predictors of lower global cognitive performance. However, exploratory analyses showed that the systolic BP variability in semi-upright position was an independent predictor of matrix reasoning (B = 0.08 ± .03, P-value = 0.005), whereas heart rate variability in semi-upright position was an independent predictor of the executive function score (B = -6.36 ± 2.55, P-value = 0.02). We conclude that myogenic vascular and sympathetic modulation of systolic BP do not contribute to reduced global cognitive performance in treated hypertensive subjects. Nevertheless, our results suggest that both systolic BP and heart rate variability might be associated with modulation of frontal lobe cognitive domains, such as executive function and matrix reasoning.

Occupation is recognized as a modifiable factor related to cognitive reserve in older adults.To examine the association between levels of complexity in lifelong occupations and cognitive performance in later life.A cross-sectional study of older adult users (aged 65 or more) of a private health care plan, resident in the north zone of Rio de Janeiro City, Brazil, and participating in the Rio de Janeiro section of the Study of Fragility in Brazilian Older Adults (FIBRA-RJ). Cognitive performance scores were obtained using the Mini-Mental State Examination. The level of complexity of their work was assessed in three domains: work with data, persons and things. Associations between the complexity of work in each domain and cognitive performance were evaluated using multivariate linear regression, adjusted for socio-demographic variables and duration of occupation.A total of 624 older adults (94% of the study group) performed lifelong work activities. Among those working with data, the high complexity group had cognitive performance scores 1.08 points higher (P0.05) than low complexity. In work with things, scores in the intermediate complexity group were 0.53 points higher (P0.05) than low complexity. There was no statistically significant difference in the cognitive performance between levels of complexity of work with people.Complexity in work with data and things was associated with better cognitive performance in later life, independent of age, schooling, income and duration of occupation.

Purpose This study aimed to investigate the associated factors with fear of falling in community-dwelling older adults with and without diabetes mellitus. Methods Data from the Frailty in Brazilian Older People Study (FIBRA-BR), involving 4449 individuals aged 65 years or older (19.2% with diabetes), were analyzed. The potential factors associated with fear of falling included sociodemographic data, chronic diseases, health-related variables and functional capacity measures. Logistic regression analysis was performed to identify the factors associated with fear of falling. Results Female gender, arthritis or rheumatism, negative health self-perception, frailty, lower Lawton Scale score and reduced gait speed were independently associated with fear of falling in both groups. Factors associated with fear of falling specific to non-diabetic older adults were depression, visual impairment, falls in the previous 12 months, obesity, depressive symptoms, higher Katz Index score and decreased handgrip strength. Lower Mini-Mental State Examination score was an associated factor with fear of falling only in those with diabetes. Conclusion The factors associated with fear of falling did differ between non-diabetic and diabetic older adults. Health care professionals should consider such differences when planning their therapeutic approaches for a successful management of fear of falling in these older populations.

Aims: To describe the overall prevalence of dementia syndrome and its major subtypes among elderly clients of a private health care plan and to ascertain the association between this syndrome and socioeconomic characteristics. Methods: A survey was organized in two stages: screening for cognitive impairment and diagnostic evaluation. The study population comprised 683 elderly subjects (aged >67 years), an expanded sample of 7,486 individuals, of the database of the FIBRA-RJ, which evaluated clients of a private health care plan residing in northern districts of the municipality of Rio de Janeiro, Brazil. The diagnosis of dementia was obtained according to DSM-IV criteria. Results: A total of 115 individuals were diagnosed with dementia, resulting in a prevalence of 16.9% (95% CI = 14.4–19.8). The association was strongest among older age groups, i.e. 85–89 years old (prevalence ratio = 8.85; 95% CI = 2.11–37.11) and 90 or more years old (prevalence ratio = 8.85; 95% CI = 2.11–37.11), and among illiterate people (prevalence ratio = 2.77; 95% CI = 1.07–7.19). Sex, personal income and marital status displayed no association with dementia. Conclusion: The prevalence of dementia was higher than found by population-based studies. These findings point to a possibility of a high demand for specialized services among older adults served by the private health care sector.

OBJECTIVE: Frailty syndrome can be defined as a state of vulnerability to stressors resulting from a decrease in functional reserve across multiple systems and compromising an individual's capacity to maintain homeostasis. The purpose of this study was to determine the prevalence of frailty and its association with social and demographic factors, functional capacity, cognitive status and self-reported comorbidities in a sample of community-dwelling older individuals who are clients of a healthcare plan. METHODS: We evaluated 847 individuals aged 65 years or older who lived in the northern area of the city of Rio de Janeiro, Brazil. The subjects were selected by inverse random sampling and stratified by gender and age. To diagnose frailty, we used the scale proposed by the Cardiovascular Health Study, which consisted of the following items: low gait speed, grip strength reduction, feeling of exhaustion, low physical activity and weight loss. The data were collected between 2009 and 2010, and the frailty prevalence was calculated as the proportion of individuals who scored positive for three or more of the five items listed above. To verify the association between frailty and risk factors, we applied a logistic regression analysis. RESULTS: The prevalence of frailty syndrome was 9.1% (95% confidence interval [CI], 7.3-11.3); 43.6% (95% CI, 40.3-47) of the individuals were considered robust, and 47.3% (95% CI 43.8-50.8) were considered pre-frail (p

Objective To determine the association between body composition and frailty in older Brazilian subjects. Material and methods This is a Cross-sectional study called FIBRA-BR and developed in community Brazilian aged ≥65 (n = 5638). Frailty was assessed according to Fried et al. definition and body composition was determined by BMI, waist circumference and waist-hip ratio. Results The lowest prevalence of frailty was observed in subjects with BMI between 25.0 and 29.9 kg/m2. Subjects with a BMI Conclusion Undernutrition is associated with pre-frailty and frailty in Brazilian elderly subjects, whereas obesity is associated only with pre-frailty. Overweight seems to have a protective effect against the syndrome. The excess of abdominal fat is associated with both profiles independent of the BMI.

Population aging is a global trend that has drawn attention to policies to encourage a productive life and delayed retirement. Thus, it is necessary to expand our understanding of the effects of work on health indicators and well-being in old age. The purpose of this study was to determine the association of permanency in the labor market with sociodemographic and medical factors and life satisfaction in elders. We used the database from Study FIBRA-RJ including elderly (aged65) clients of a private health care plan who resided in northern districts of the municipality of Rio de Janeiro. Among the 626 participants, 82 (13,1%) maintained paid jobs. Multiple logistic regression showed that the odds of remaining working among the elderly were higher for men; and those with 9 years of studies or more, and those with high income; and those with no disabling clinical conditions and with higher satisfaction with life. This study confirms that work activities in old age are associated with better social and physical health conditions. Moreover, we observed that the maintenance of work activities was associated with higher life satisfaction, independent of socioeconomic and clinical characteristics in old age.O envelhecimento da população é uma tendência mundial e chamou a atenção para as políticas de incentivo à vida produtiva e de adiamento da aposentadoria. Assim, cabe ampliar a compreensão dos efeitos do trabalho sobre os indicadores de saúde e bem-estar na velhice. O objetivo deste estudo foi verificar a associação da permanência no mercado de trabalho com fatores sociodemográficos, clínicos e de satisfação com a vida em idosos. Utilizou-se a base de dados do Estudo FIBRA-RJ que inclui idosos (idade65 anos) clientes de uma operadora de saúde, residentes na zona norte do município do Rio de Janeiro. Dentre os 626 participantes, 82 (13,1%) mantinham atividade de trabalho remunerado. Os resultados da regressão logística múltipla mostraram que as chances de permanecer trabalhando eram maiores para homens; para aqueles com 9 anos ou mais de estudos; com alta renda; sem condições clínicas crônicas incapacitantes e aqueles com maior satisfação com a vida. Este estudo confirma a associação das atividades de trabalho na velhice com melhores condições sociais e de saúde física. Além disso, observou-se que a manutenção das atividades de trabalho estava associada com a maior satisfação com a vida independente das características socioeconômicas e clínicas na velhice.

Frailty is a state of multisystem physiological vulnerability related to aging and an increased risk of adverse outcomes. This study aimed to evaluate the prevalence and associated factors of frailty in the Fibra-JF Study, Minas Gerais, Brazil. We selected a random sample of 461 individuals aged 65 years or more stratified by territorial unit, gender and age. The frailty syndrome was established by the presence of three or more of five items: a feeling of exhaustion, low handgrip strength, slow gait speed, weight loss, and low caloric expenditure. The mean age was 74.4 (SD ± 6.8) years, 69.6% were women and 71.9% white. The prevalence of frailty was 5.2%; 49.9% was from pre-frail subjects. Advanced age (OR: 6.4; CI 1.76-23.8), impairment of the basic activities of daily living (OR: 5.2, CI 1.1-23.1) and self-perception of poor health (OR: 0.13, CI 0.03-0.4) were associated with frailty. In this study, a substantial number of individuals was classified as frail, while half of the sample was at risk of progression towards this condition, suggesting that it is urgent to adopt public health measures focused on frailty prevention and reduction of associated adverse health outcomes.Fragilidade é um estado de vulnerabilidade fisiológica multissistêmica relacionada à idade e a um risco aumentado de desfechos adversos. O objetivo do presente estudo foi avaliar a prevalência e os fatores associados à fragilidade no estudo FIBRA em Minas Gerais, Brasil. Selecionou-se uma amostra aleatória, estratificada por unidade territorial, sexo e idade, de 461 indivíduos, com 65 anos ou mais. A fragilidade foi estabelecida pela presença de três ou mais de cinco itens: sensação de exaustão, baixa força de preensão manual, velocidade da marcha lenta, perda de peso e baixo gasto calórico. A média de idade foi de 74,4 anos (DP± 6,8), 69,6% eram mulheres e 71,9% brancos. A prevalência de fragilidade foi de 5,2%; 49,9% foram de indivíduos pré-frágeis. Idade avançada (OR: 6,4; IC 1,76-23,8), comprometimento das atividades básicas de vida diária (OR: 5,2; IC 1,1-23,1) e auto percepção de saúde ruim (OR: 0,13; IC 0,03-0,4), foram associados à fragilidade. No presente estudo, um número substancial de indivíduos apresentou-se frágil, enquanto que metade da amostra estava sob risco de progressão para esta condição, sugerindo que é urgente a adoção de medidas de saúde pública com objetivo de prevenção e redução de complicações.

This study aimed to estimate the quartile distribution on the cognitive assessment of normal elderly with low education as measured by the Cambridge Cognitive Examination (CAMCOG). A sample of 292 elderly (> 65 years of age), screened for dementia and depression, were assessed using the CAMCOG. The CAMCOG scores of normal subjects (n = 206) were stratified according to age (65-69, 70-74, 75-79, > 80) and schooling (illiterate, 1-4, and > 5 years of formal education). Mean age was 72.8 (± 3.5) and mean schooling was 3.5 years (± 3). The mean score on the CAMCOG was 71 (± 12.7). The scores at the first quartile for illiterate/1-4 years of schooling were 58/62 (65-69 years), 52/63 (70-74 years), 48/67 (75-79 years) and 46/64 (> 80 years), respectively. There was a significant difference in the CAMCOG quartiles according to education and age. This study provides normative data on the CAMCOG of elderly people with low educational levels which may be clinically useful. Este estudo objetivou estimar a distribuição em quartis do Cambridge Cognitive Examination (CAMCOG) de idosos normais com baixa escolaridade. Foram selecionados 292 idosos (> 65 anos) que fizeram avaliação para detectar demência ou depressão (DSM-IV). Os resultados do CAMCOG dos indivíduos normais (n = 206) foram estratificados por idade (65-69, 70-74, 75-79 e > 80) e escolaridade (sem escolaridade, 1-4 anos e > 5 anos de estudo formal). A média de idade foi 72,8 anos (± 3,5), a de escolaridade 3,5 (± 3) anos e a pontuação do CAMCOG foi 71 (± 12,7). Os escores do quartil inferior do CAMCOG de analfabetos/1-4 anos de estudo foram 58/62 (65-69 anos), 52/63 (70-74 anos), 48/67 (75-79 anos) e 46/64 (> 80 anos), respectivamente. Verificou-se diferença significativa no desempenho dos quartis do CAMCOG quanto à escolaridade e relação inversamente proporcional com a idade. Este estudo oferece dados normativos do CAMCOG para idosos brasileiros com baixa escolaridade que podem ser úteis no contexto clínico.

The present study estimated the prevalence of fear of falling in older adults, and its associations with clinical, functional and psychosocial factors.Data from the Research Network Frailty in Brazilian Older People, specifically the Rio de Janeiro Study involving participants aged 65 years and older residing in the city of Rio de Janeiro, Brazil, were analyzed. Fear of falling was assessed by the Brazilian version of Falls Efficacy Scale-International. The following variables were assessed: history of falls, fracture after fall, number of comorbidities, number of medications, hospitalization in the previous year, use of walking support device, functional dependency in activities of daily living (including instrumental activities), hearing and visual impairments, hand grip strength, walking speed, self-rated health, depressive symptoms, cognitive impairment, living alone, social support, and activity level. Associations were evaluated by multiple logistic regression.Among the 742 participants, 51.9% had a fear of falling, which was more prevalent in women and older participants. Fear of falling was associated with a history of one to two falls (odds ratio [OR] 2.18; 95% confidence interval [CI] 1.42-3.36), three or more falls (OR 2.72, 95% CI 1.10-6.70), use of seven or more medications (OR 1.70, 95%CI 1.04-2.80), hearing impairment (OR 1.66, 95% CI 1.10-2.49), functional dependence in activities of daily living (OR 1.73, 95% CI 1.07-2.79), diminished gait speed (OR 1.64 95% CI 1.04-2.58), fair self-rated health (OR 1.89, 95% CI, 1.30-2.74), poor/very poor self-rated health (OR 4.92, 95% CI 1.49-16.27) and depressive symptoms (OR 1.68, 95% CI 1.07-2.63).The prevalence of fear of falling was high in this population, and was associated with history of falls, use of seven or more medications, hearing impairment, functional dependency in activities of daily living, diminished walking speed, fair and poor/very poor self-rated health and depressive symptoms.

Few studies have been published on the use of the Cambridge Cognitive Examination Test - Revised (CAMCOG-R) for cognitive assessment of low educational level older adults. The aim of the present study was to determine the accuracy of the Brazilian version of the CAMCOG-R (Br-CAMCOG-R) within a sample of low educational level and illiterate older adults.The Br-CAMCOG-R was administered to outpatients in a public geriatric clinic. The diagnosis of dementia was based on the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition criteria. The receiving operator characteristic curves were plotted, and the best trade-offs between sensitivities and specificities were calculated.A total of 189 participants were evaluated. The mean age was 77 ± 6.9 years. The mean educational level was 3.1 ± 2.2 years. The mean test score was 66.5 ± 13.1 points; there were 56 (29.6%) participants with dementia. The best cut-off score for illiterate participants was 50/51; sensitivity, specificity and area under the curve (AUC) were 69%, 69% and 0.75, respectively; for participants with a low educational level, the best cut-off point was 60/61; the sensitivity, specificity and AUC were 83%, 85%, and 0.93, respectively; for participants with a middle educational level, the best cut-off point was 69/70; the sensitivity, specificity and AUC were 90%, 76% and 0.91, respectively.The Br-CAMCOG-R was useful for identifying cases of dementia among older adults with middle and low levels of literacy, but inadequate for the illiterate individuals.

To assess the criterion validity of the Brazilian version of the Informant Questionnaire on Cognitive Decline on the Elderly (IQCODE-BR), and analyze the influence of educational level and age of both the elderly and the informants on the questionnaire scores.The study design was a cross-sectional study with a convenience sample. Convergent validity was assessed using the Mini-Mental State Examination, and the accuracy of the IQCODE-BR was evaluated by receiver operating characteristic curve analysis. Multivariate logistic regression analysis was carried out to determine the influence of sociodemographic characteristics on IQCODE-BR scores.A total of 169 elderly individuals participated in the study, of which 35.5% were diagnosed with dementia. There was no statistically significant association between the IQCODE-BR scores, and the age and educational level of both the elderly and the informants. The cut-off point for greater accuracy was 3.52, with sensitivity of 83.3% and specificity of 80.7%. The area under the receiver operating characteristic curve was 0.83 (95% CI 0.766-0.893). There was a negative and moderate correlation between IQCODE-BR and the Mini-Mental State Examination scores (P0.01).This study suggests that the IQCODE-BR is a valid tool for screening of dementia and that IQCODE-BR scores do not seem to be influenced by age, educational level and other factors associated with the informants. However, further studies are required to evaluate informant characteristics, such as anxiety states, depression and burden level.

FUNDAMENTO: A hipertensao arterial tem sido associada a reducao do desempenho cognitivo, contudo a literatura e conflitante. OBJETIVO: Comparar o desempenho cognitivo entre idosos normotensos ("N"; n = 17; idade 68 ± 1; pressao arterial = 133 ± 3/74 ± 2 mmHg) e hipertensos ("H"; n = 28; idade 69 ± 1, pressao arterial = 148 ± 4/80 ± 1 mmHg) com pelo menos cinco anos de escolaridade. METODOS: A avaliacao neuropsicologica ampla constou do "Cambridge Cognition-Revised" (CAMCOG-R), dos "Trail Making Test A and B" (TMT A e B) e do "Rey Auditory Verbal Learning Test" (RAVLT). RESULTADOS: Os idosos hipertensos apresentaram menor escore do CAMCOG-R (N = 87,6 ± 1,8; H = 78,6 ± 1,4; p = 0,002). Os idosos hipertensos necessitaram de maior tempo para realizar o TMT A e B (TMT A: N = 39 ± 3s; H = 57 ± 3,4s; p = 0,001; TMT B: N = 93 ± 7s; H = 124 ± 7s; p = 0,006), o que tambem e demonstrado pelos percentis significativamente menores obtidos nestes testes. O somatorio do RAVLT foi significativamente menor nos idosos hipertensos (N = 51,8 ± 1,7; H = 40,7 ± 1,5; p < 0,0001). Mesmo ajustado para idade, sexo, escolaridade e sintomas de depressao, a hipertensao arterial foi um fator preditor independente do desempenho cognitivo medido pelo CAMCOG-R, TMT A e o somatorio do RAVLT. CONCLUSAO: O desempenho cognitivo em idosos hipertensos e menor do que em idosos normotensos.

To investigate the association between frailty syndrome and cognitive performance in the older adults and the effect of schooling and age on this association.Data on frailty in older adults from Phase 1 of the FIBRA-RJ Study were analyzed, relating to 737 customers of a private health care provider, aged 65 and over, living in Rio de Janeiro, Southeastern Brazil, between January 2009 and January 2010. Data on socioeconomic and demographic characteristics, medical conditions and functional capacity were collected. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE). Individuals who exhibited three or more of the following features were considered to be frail: unintentional weight loss (≥ 4.5 kg in the last year); feeling self-reported exhaustion, low grip strength, low physical activity level and slowness. The association between frailty and cognitive performance was evaluated using multivariate logistic regression, with adjustment for medical conditions, activities of daily living and socioeconomic variables. We evaluated the age and schooling as possible effect modifiers in this association.The frail subjects had a higher prevalence of low cognitive performance, compared to not frail or pre-frail, in the three age groups studied (65-74; 75-84; ≥ 85 years), p0.001. After adjustment, the association between frailty and cognitive performance was found among older adults individuals aged 75 and older, with an OR(adj)= 2.78 (95%CI 1.23;6.27) for those aged 75 to 84 and OR(adj)= 15.62 (95%CI 2.20;110.99) for 85 and older. The age variable was an effect modifier in the association between frailty and cognitive performance, χ²(5) = 806.97, p0.0001; the same was not the case with schooling.Frailty syndrome is associated with cognitive performance in the aging. Age proved to be an effect modifier in this association. The oldest patients showed a more significant association between the two phenomena.

The objective of this study was to determine the risk profile and factors associated with frailty in elderly community residents. The population consisted of individuals 65 years or older living in the northern districts of the city of Rio de Janeiro, Brazil, and who held private health insurance policies. The cross-sectional study was done at baseline in a cohort with a sample (N = 764) stratified by gender and age. Risk stratification used probability of repeated admissions (PRA) as the screening instrument. Following bivariate analyses, logistic regression analyses were performed to study associations between probability of repeated admissions and socio-demographic, health-status, functional, and cognitive variables. Of the total sample, 6.7% were classified as high risk. Cancer, falls, chronic obstructive pulmonary disease, use of medication, receiving a visit from a health professional, being bedridden at home, living alone, and level of activities of daily living were statistically associated with risk of hospitalization. The instrument appeared to be useful for stratifying risk in the elderly.

We would like to congratulate Aprahamian et al. (2011) for their initiative to investigate the psychometric properties of the Cambridge Cognition Examination (CAMCOG) in assessing the cognitive status of the Brazilian elderly. This instrument is very frequently used in Brazil, but its measure characteristics have not yet been fully determined. Of course, cross-cultural adaptation and validation are rarely a simple procedure, often demanding a research program to completely adapt the tool to the specific language, culture, and selected population. In our opinion, the paper “Can the CAMCOG be a good cognitive test for patients with Alzheimer's disease with low levels of education?” (Aprahamian et al., 2011) is welcome as another trial by Brazilian scientists in this ongoing process. Notwithstanding, we believe that some comments about the methodological aspects of the paper are in order.

This article concerns the first phase of the cross-cultural equivalence of Section A in the Cambridge Examination for Mental Disorders of the Elderly-Revised Version (CAMDEX-R), a clinical interview for dementia diagnosis. Evaluating conceptual and item equivalencies involved a literature review and expert groups. Semantic equivalence involved translations of the original into Portuguese and back-translations, with analysis of the versions and the original text; meetings with experts; discussions with 52 elders using the focus group technique; further meeting with experts; pretesting on 35 elders; and elaboration of the final version. For the reliability analysis, the version was applied to 160 patients. Inter-observer reliability was nearly perfect in all sub-sections of present state and in individual items of past medical history. Test-retest reliability was moderate or higher in the sub-sections and substantial or nearly perfect in 70% of the items in past history. The Brazilian version shows satisfactory equivalence to the original and good reliability levels.

This paper presents the results of the first four steps (conceptual, item, semantic, and operational equivalences) of cross-cultural adaptation to Portuguese of the Cambridge Cognitive Examination-Revised (CAMCOG-R). The process was based on the theoretical model proposed by Herdman et al., which includes not only the four steps described above, but also measurement and functional equivalences, not evaluated in the current study. A panel of experts evaluated whether all dimensions that comprise the CAMCOG-R were present in Brazilian reality. Two translations and back-translations were performed, in addition to the 'focus group' technique. The Brazilian Portuguese version of the CAMCOG-R (Br-CAMCOG-R) was developed, maintaining the 69 items from the original instrument, with different levels of difficulty. It was then applied to 196 elders, with the test lasting an average of 43 +/- 9.4 minutes, and an average total score of 67 +/- 14.8 points. The Br-CAMCOG-R can be a useful tool for the cognitive evaluation of elders that tested positive during initial screening.

The study' goal was to evaluate the reliability of the Cambridge Cognitive Examination Revised-Brazilian version (Br-CAMCOG-R), a neuropsychological battery measuring the global cognitive function. It was applied on 123 elders and retested at a mean interval of 30.7 days; 60 were evaluated by two raters at the same time. The intraclass coefficient for the set of items and for the subscales varied from 0.93 to 0.98. In the retests the agreement was nearly perfect for the set of items. There was no expressive range in the stability of the instrument for sex, age, schooling, or for the presence of dementia. The Cronbach' alpha of the set of items of the test was high (0.89). The Br-CAMCOG-R has obtained a high level of stability with time, agreement among raters, and optimum internal consistency; it can be useful for epidemiological studies and in specialized clinics to evaluate cognitive functions in elders. O objetivo deste estudo foi avaliar a confiabilidade da versão brasileira do Cambridge Cognitive Examination Revised (Br-CAMCOG-R), uma bateria neuropsicológica que mede a função cognitiva global. Ele foi aplicado em 123 idosos e reaplicado no intervalo médio de 30,7 dias; 60 destes idosos foram avaliados por dois aferidores ao mesmo tempo. O coeficiente de correlação intraclasse para o conjunto dos itens do teste assim como das subescalas variou de 0,93 a 0,98. No reteste a concordância foi quase perfeita para o conjunto dos itens. Não houve variação significativa na estabilidade do instrumento entre os sexos, idade, escolaridade ou presença de demência. O alfa de Cronbach para o conjunto dos itens do teste foi alta (0,89). O Br-CAMCOG-R teve altos níveis de estabilidade no tempo, entre os examinadores e ótima consistência interna; pode ser útil em estudos epidemiológicos assim como em clínicas especializadas na avaliação das funções cognitivas dos idosos.

OBJECTIVE: To compare the accuracy of four scales, and to determine the inter-rater reliability and the influence of schooling on Clock Drawing Test performance in screening for dementia in elderly with low educational level. METHOD: Design: Criterion validation, concurrent type. Setting: Outpatient unit of Universidade do Estado do Rio de Janeiro Hospital, Brazil. Participants: A total of 306 individuals (> 65 years) were assessed by a geriatrician and a neuropsychologist using functional and cognitive instruments. The diagnosis of dementia was established by consensus in a meeting between these professionals. Four different researchers blinded as to the cognitive status of the patients scored the Clock Drawing Test using Shulman's, Sunderland's, Manos', and Wolf-Klein's methods; and a fifth researcher assessed Manos' method for an inter-rater reliability study. RESULTS: The data of 211 individuals (≤ 4 years of schooling) were analyzed. The sensitivity and specificity of the four methods were similar (about 65%). The inter-rater reliability of Manos' method was excellent (ICC = 0.944). The areas under the ROC curves were small (0.657 to 0.681), and the differences between them were not statistically significant. CONCLUSIONS: The Clock Drawing Test is a reliable but not valid test to screen for dementia in older outpatients with 4 or less years of formal schooling. OBJETIVO: Comparar a acurácia de quatro escalas de avaliação e determinar a confiabilidade inter-aferidor e a influência da escolaridade, no desempenho do Teste do Desenho do Relógio para detecção de demência em idosos com baixo nível educacional. MÉTODO: Delineamento de estudo: Validação de critério, tipo concorrente. Local de estudo: Ambulatório do Hospital da Universidade do Estado do Rio de Janeiro, Brasil. Participantes: 306 indivíduos (> 65 anos) submetidos à avaliação funcional e cognitiva por um geriatra e um neuropsicólogo; uma reunião de consenso entre estes profissionais avaliou a presença de demência. Quatro pesquisadores, que desconheciam o status cognitivo dos indivíduos, pontuaram o Teste do Desenho do Relógio - métodos de Shulman, Sunderland, Manos e Wolf-Klein, e um quinto pesquisador repetiu o método de Manos para o estudo de confiabilidade inter-aferidor. RESULTADOS: 211 indivíduos (≤ 4 anos de escolaridade) tiveram seus dados analisados. A sensibilidade e a especificidade dos quatro métodos foram similares e variaram em torno de 65%. A confiabilidade inter-avaliador foi excelente (ICC = 0,944). As áreas sob as curvas ROC foram pequenas (0,657 a 0,684) e as diferenças entre elas não foram estatisticamente significativas. CONCLUSÕES: O Teste do Desenho do Relógio é um instrumento confiável, mas não é válido para o rastreio de demência em pacientes idosos com quatro anos ou menos de escolaridade.

The Geriatric Depression Scale for screening depressive symptoms in the elderly has not been assessed in elderly outpatients who seek primary health care in Brazil. The objective was to determine the validity of the Short Scale for Major Depressive Episode or Dysthymia (GDS-15) in elderly outpatients.The scale was applied in 302 subjects with 65 years and older and then examined by an independent geriatrician, blinded to the results. Major depression and dysthymia were diagnosed using the Diagnostic and Statistical Manual of Mental Disorders-IV criteria. Sensitivity and specificity were calculated at several cutoff values and a Receiver Operating Characteristic curve was plotted.The best equilibrium was at the cutoff value of 5/6 showing 81% sensitivity and 71% specificity; the area under the Receiver Operating Characteristic curve was 0.85 (95% CI: 0.79-0.91).The GDS-15 can be used for screening depressive symptoms in Brazilian elderly outpatients. The previously suggested cutoff value of 5/6 is adequate.

Background The dimensional structure, effective number of item responses and item redundancies are controversial features of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) requiring more light. The aims of the present study are to revisit the dimensional structure and propose a shorter version of the instrument. Methods The sample comprised 652 elderly and their informants, either attending a geriatric service of a public university clinic or enrolled in a health care provider database in Rio de Janeiro, Brazil. A Confirmatory Factor Analysis (CFA) first tested the originally proposed one-dimensional structure comprised of 26 items. This was followed by sequential Exploratory Structural Equation Model (ESEM) to evaluate alternative models, in particular a bi-dimensional solution. The identification of residual correlations (RC) lead to a shortened 20-item model, which was tested further via CFA. Results The original model fitted poorly (RMSEA = 0.073; 90 % CI: 0.069-0.077). Regarding the two-dimensional model, the exploratory procedure (ESEM) indicated several RCs and a lack of factor-based discriminant validity. The ensuing CFA on the one-dimensional model with freely estimated RCs showed an adequate fit (RMSEA = 0.051; 90 % CI: 0.047-0.055). Addressing the identified RCs, the CFA on the abridged 20-item version also showed an adequate fit (RMSEA = 0.058; 90 % CI: 0.053-0.064) and no further RCs. Conclusion A one-factor dimensional structure and a reduced version with 20 locally independent items were the most tenable solution. However, although promising, this simpler structure requires further examination before it may be fully supported and recommended.