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This study aimed to evaluate the efficacy and toxicity of 4-day chemotherapy with methotrexate, etoposide, and actinomycin D (MEA) for patients who were diagnosed with choriocarcinoma and high-risk gestational trophoblastic neoplasia (GTN). Between January 1999 and December 2015, 29 patients were treated with 4-day MEA after being diagnosed with choriocarcinoma or high-risk GTN. Complete remission to 4-day MEA and adverse effects were retrospectively evaluated. The complete remission rates were 79.3% (23/29) and 87.5% (21/24) in all patients and in those who received 4-day MEA as first-line therapy, respectively. Of six patients who developed drug resistance to 4-day MEA, three patients showed complete remission by other treatments, while the other three patients died of the disease. The major adverse effects were leukocytopenia, anemia, and nausea. Of 23 patients who were cured with 4-day MEA, treatment was changed to the etoposide and actinomycin D (EA) regimen in 14 patients, because of leukocytopenia, hepatotoxicity, and stomatitis. Among 20 patients who required hormonal therapy, 15 patients showed normal menstrual cycles after therapy. Five patients had nine conceptions (seven term live births and two spontaneous abortions). No babies were premature or had low birth weight nor did they have congenital anomalies. The results suggest that the efficacy and the adverse effects of 4-day MEA for choriocarcinoma and high-risk GTN may be the same level as EMA/CO. However, further study will be needed for determining the criteria of changing the treatment regimen from 4-day MEA to the EA regimen.

The purpose of this study was to investigate the relationship between personality and characteristics in collage work. Seventy undergraduates filled the Yatabe-Guilford (YG) personality test and produced a piece of collage work. The YG personality types were not different in terms of collage work characteristics. However, emotional adaptation and introvert/extrovert scores were reflected in the number of cuttings used in the piece. General activity score was reflected in the number of vehicle pictures used. Those who used an eye picture had a tendency to be depressed and lacking in confidence. Those who used a "stone circle" picture tended to be more emotionally adapted and extroverted. The results suggested a possibility that personality traits were reflected in specific characteristics in collage work.

An application of collage as an art form has been made in clinical psychology, and has been established as collage therapy. This paper attempted to answer the following questions: What kind of behavior people show during production of collage work; how the production behavior differs from person to person; what causes the behavior differences. The framework of creative problem solving and behavior analysis technique with VTR were used, and behavior characteristics of mentally retarded subjects (N = 20) were compared with non-retarded adults (N = 20). Results revealed three behavior patterns: Whole linear type ([SEAF]n), partially repeated linear type ([SE]n and [AF]m), and circuit type ([SEA]n and [AF]m) from the analysis of transition probability of four fundamental action elements (search [S], extraction [E], arrangement [A] and fixation [F]) of collage work production. The difference in the production process of each subject may be attributed to the difference in proportions of the three behavior patterns. The proportion difference in turn appeared to reflect that on the global-local dimension in the work production plan.

The purpose of this study was to analyze the process by which collage material was chosen, by looking at the structure in material pictures in terms of their transitive chain and connection strength, and investigate the relationship between planning process and artwork characteristics. For the purpose, successive choices of material pictures were analyzed, and graph theory applied. Forty mentally retarded and normal subjects participated in an experiment of collage work production. The transitive chain of collage material pictures for normal subjects was long (deep) and showed story development, and connections among material pictures were strong. On the other hand, the chain for retarded subjects was short (shallow), without story development, and the connections weak. These results showed a correspondence between planning process and artwork characteristics. It was suggested that the method used in this study was effective in analyzing the structure of collage as well as Hakoniwa work.