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The results of treatment in 674 oncological patients in a special department of accessory therapy have been studied. The patients admitted were previously subjected to various kinds of radical surgery. The analysis has evidenced that due to a careful dynamic exploration of patients and pathogenetic therapy with a protective regimen and labor therapy, the results of surgical treatment in patients with cancer of the stomach, lung and mammary gland were found to be considerably improved. This is especially evident from observations over patients with lung cancer. Among 168 patients followed up since 1965 up to date 126 patients (75%) show no signs of tumor recurrence. Thus, there can be no doubts as to the rationality of further elaboration of rehabilitation measures in oncological patients.

In 95 workers engaged in benzidine production the results of the cutaneous delayed hypersensitivity response to the injection of tissue embryonal antigen were studied, 76 of them were additionally examined for application of 2,4-dinitrochlorobenzene (DNCB). Studies on the state of the immune response of the workers' organism were conducted in association with clinical and cytoscopic findings. The immunological tests applied during prophylactic examinations revealed, according to objective signs, a group of persons with immunological defects. And just in this group pretumor conditions and occupational vesical tumors were detected. The results of the authors' observations made it possible to recommend an application of the tests reflecting the state of cell immunity, to determine immunological defects in such workers as adjuvant methods for periodic prophylactic examinations.

Under study were the factors of antitumor immunity (RHDT, the reaction of microprecipitation, the functional activity of lymphocytes, RFC and RBT) in 104 patients with cancer of the corpus uteri. It was found that most patients show an impaired immunobiological response, manifested in higher percentage of positive results with RHDT performed with the tumor antigen, and the reaction of microprecipitation with tumor and embryonal antigens, more week RFC and RBT. Immunological indices are getting worse with the process spread and are improved following the combination therapy. The process of treatment however (surgery and radiotherapy) renders a negative effect on immune indices. Normalization of the latter is noted not earlier than 1-3 years after the treatment.

The work is concerned with studies of the polysaccharide complex (PSC) of human ovarian tumor--ovarian serous cystadenocarcinoma in the Hoigne microprecipitation reaction. It was found that PSC of ovarian tumor tissue is a serologically active preparation. However, the results of the investigation as well as the potentialities of the technic used makes it impossible to state definitely the specificity of the ovarian tumor PCS in the Hoigne microprecipitation reaction.

Under study were immunological indices--the reaction of microprecipitation (tumor and embryonal antigens) and HRDT (tumor and tuberculine antigens) in 305 patients with cancer of the uterine cervix. It was found that most patients showed impaired immune responses: an increased number of persons with specific antibodies circulating in blood serum and increased hypersensitivity of of delayed type. The percentage of positive reactions of microprecipitation and HRDT increases as the tumor spreads. The methods of combined therapy generally improve immunological indices, however, the process starts 1-3 years following the treatment.