Author: "Wingerup, L." / Topic: female - Searchworks@Jio Institute Digital Library Search Results

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Start Over Author "Wingerup, L." Topic female

Author: Niels Uldbjerg, Ekman, G., Herltoft, P., Malmström, A., Ulmsten, U., and Wingerup, L.
Subjects: Macromolecular Substances, Prostaglandins E, Dermatan Sulfate, Cervix Uteri, Dinoprostone, Microbial Collagenase, Connective Tissue, Pregnancy, Animals, Humans, Female, Proteoglycans, Collagen, Rabbits
Abstract: Udgivelsesdato: 1983-null A survey of connective tissue in general and human cervical connective in particular is presented. It is concluded that about 90% of the human cervix consists of fibrous connective tissue which, according to the composition of the collagen and the proteoglycans, is very similar to that in skin and sclera. The high activity of collagenase probably gives the cervical connective tissue from pregnant women its potential to ripen following prostaglandin treatment. Electron microscopical examination has revealed an increased amount of amorphous substance after such treatment. This may be caused partly by degraded collagen fibers and partly by newly synthesized proteoglycans.
Published: 1983

Author: Ekman, G., Axel Forman, Ulmsten, U., and Wingerup, L.
Subjects: Adult, Pregnancy, Prostaglandins E, embryonic structures, Humans, Female, Cervix Uteri, Abortion, Missed, Abortion, Therapeutic, Fetal Death, Gels, reproductive and urinary physiology
Abstract: To terminate pregnancy 15 women with an established diagnosis of missed abortion or intrauterine dead fetuses were treated with 1.0 mg Prostaglandin E 2 in viscous gel applied as a single intracervical dose. -- Abortion was induced after a mean of 7.0 hours in 8 patients with a mean gestational age of 15.0 weeks, and a subsequent evacuation of the uterine cavity was easily performed. -- Complete abortion/delivery was obtained in 7 patients with a gestational age of 33 weeks. The over-all mean induction/delivery time was 7.5 hours. -- Apart from pain related to uterine contractions no side effects were observed and no complications occurred. It is concluded that the present technique represents a promising alternative in the treatment of patients with missed abortion or intrauterine dead fetuses.

Author: Niels Uldbjerg, Ekman, G., Malmström, A., Sporrong, B., Ulmsten, U., and Wingerup, L.
Subjects: Pregnancy, Prostaglandins E, Humans, Female, Cervix Uteri, Glycosaminoglycans
Abstract: Udgivelsesdato: 1981-Jan-31

Author: Niels Uldbjerg, Ekman, G., Malmström, A., Ulmsten, U., and Wingerup, L.
Subjects: Prostaglandins E, Synthetic, Microbial Collagenase, Body Water, Connective Tissue, Humans, Female, Cervix Uteri, Collagen, Glycosaminoglycans
Abstract: Udgivelsesdato: 1983-null Intracervical application of prostaglandin E2 in the late first trimester induces (1) softening of the cervix tissue; (2) increase in sulfated glycosaminoglycans (18 +/- 12%, mean +/- SEM); (3) no change in hyaluronic acid and water; (4) decrease in pepsin-extractable collagen, and (5) apparent decrease in collagenase. A high activity of collagenase in combination with a replacement of collagen with sulfated glycosaminoglycans may be of importance for the ripening process.

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