1. Management and outcomes of patients for non-functioning pancreatic neuroendocrine tumours: a multi-institutional analysis
- Author
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Bingqing Du, Zili Shao, Yisheng Wei, Xing Wang, Wangfa Zhang, and Qing-Quan Tan
- Subjects
Male ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,FNA biopsy ,business.industry ,Perineural invasion ,Octreotide ,General Medicine ,Gastroenterology ,Pancreatic Neoplasms ,Neuroendocrine Tumors ,medicine.anatomical_structure ,Internal medicine ,medicine ,Adjuvant therapy ,Humans ,Neuroectodermal Tumors, Primitive ,Surgery ,Female ,Lymph ,Pancreas ,business ,medicine.drug ,Retrospective Studies - Abstract
BACKGROUND To analysed the short- and long-term outcomes of patients who underwent surgical resection for non-functioning pancreatic neuroendocrine tumours (NF-PNETs) to gain insights into treatment approaches for this rare and heterogeneous entity. METHODS All patients who underwent surgical resection for NF-PNETs at The Second Affiliated Hospital of Guangzhou Medical University, and West China Hospital, Sichuan University, from 2009 to 2019 were retrospectively reviewed. The data of patients was including perioperative management, pathologic analysis and follow-up. RESULTS A total of 119 cases with histologically or cytologically confirmed NF-PNETs, The mean age of the patients was 52, and 56.3% were female. Twenty-three patients received post-operative adjuvant therapy, and five of nine (55.6%) patients with distant metastasis showed recurrence 14(60.9%) G2/G3 patients without distant metastasis received post-operative therapy with octreotide. Of these 14 patients, 3 (21.4%) revealed recurrence. Univariate analysis indicated that symptoms (P = 0.03), tumour size >4 cm (P = 0.029), ENETS stages III-IV (P
- Published
- 2021