1. ASPECTS-based reperfusion status on arterial spin labeling is associated with clinical outcome in acute ischemic stroke patients
- Author
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Yu, Songlin, J, Samantha, Liebeskind, David S, Yu, Dandan, Li, Ning, Qiao, Xin J, Shao, Xingfeng, Yan, Lirong, Yoo, Bryan, Scalzo, Fabien, Hinman, Jason D, Sharma, Latisha K, Rao, Neal, Jahan, Reza, Tateshima, Satoshi, Duckwiler, Gary R, Saver, Jeffrey L, Salamon, Noriko, and Wang, Danny JJ
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Cerebrovascular ,Neurosciences ,Biomedical Imaging ,Brain Disorders ,Bioengineering ,Stroke ,Adult ,Aged ,Aged ,80 and over ,Brain Ischemia ,Cerebral Arteries ,Cerebral Infarction ,Diffusion Magnetic Resonance Imaging ,Endovascular Procedures ,Female ,Humans ,Male ,Middle Aged ,Observer Variation ,ROC Curve ,Reperfusion ,Reperfusion Injury ,Spin Labels ,Thrombolytic Therapy ,Treatment Outcome ,Acute ischemic stroke ,arterial spin labelling ,recanalization ,reperfusion ,reperfusion injury - Abstract
The purpose of this study was to develop and evaluate a scoring system for assessing reperfusion status based on arterial spin labeled (ASL) perfusion MRI in acute ischemic stroke (AIS) patients receiving thrombolysis and/or endovascular treatment. Pseudo-continuous ASL with background suppressed 3D GRASE was acquired along with DWI in 90 patients within 24 h post-treatment. An automatic reperfusion scoring system (auto-RPS) was devised based on the Alberta Stroke Program Early CT Score (ASPECTS) template, and compared with manual RPS and DWI-ASPECTS. TICI (thrombolysis in cerebral infarction) scores were graded in 48 patients who received endovascular treatment. Favorable outcomes were defined by a modified Rankin Scale score of 0-2 at three months. Auto-RPS was positively correlated with DWI-ASPECTS (ρ = 0.6, P
- Published
- 2018