1. Evaluation of the fetal QT interval using non-invasive fetal ECG technology
- Author
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Joachim Behar, Julien Oster, Terrence Chun, Reza Sameni, Douglas Y. Mah, Gari D. Clifford, Alisa Niksch, Tingting Zhu, Jessica Harrop, Cassandre Tanner, James A Greenberg, Adam Wolfberg, Jay Ward, Department of Engineering Science [Oxford], Institute of Biomedical Engineering [Oxford] (IBME), University of Oxford-University of Oxford, Technion - Israel Institute of Technology [Haifa], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Tufts University School of Medicine [Boston], Boston Children's Hospital, Seattle Children's Hospital, Brigham and Women's Hospital [Boston], College of electrical and computer engineering, Shiraz University (Shiraz University ), Mindchild Medical, Emory University [Atlanta, GA], UL, IADI, and University of Oxford [Oxford]-University of Oxford [Oxford]
- Subjects
Mean squared error ,Physiology ,0206 medical engineering ,Biomedical Engineering ,Biophysics ,02 engineering and technology ,Signal-To-Noise Ratio ,QT interval ,03 medical and health sciences ,Electrocardiography ,0302 clinical medicine ,Signal-to-noise ratio ,Physiology (medical) ,Medicine ,Humans ,Fetal Monitoring ,Fetus ,030219 obstetrics & reproductive medicine ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,medicine.diagnostic_test ,business.industry ,020601 biomedical engineering ,Term (time) ,Fetal ecg ,medicine.anatomical_structure ,Scalp ,Feasibility Studies ,Female ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Biomedical engineering - Abstract
International audience; Non-invasive fetal electrocardiography (NI-FECG) is a promising alternative continuous fetal monitoring method that has the potential to allow morphological analysis of the FECG. However, there are a number of challenges associated with the evaluation of morphological parameters from the NI-FECG, including low signal to noise ratio of the NI-FECG and methodological challenges for getting reference annotations and evaluating the accuracy of segmentation algorithms. This work aims to validate the measurement of the fetal QT interval in term laboring women using a NI-FECG electrocardiogram monitor. Fetal electrocardiogram data were recorded from 22 laboring women at term using the NI-FECG and an invasive fetal scalp electrode simultaneously. A total of 105 one-minute epochs were selected for analysis. Three pediatric electrophysiologists independently annotated individual waveforms and averaged waveforms from each epoch. The intervals measured on the averaged cycles taken from the NI-FECG and the fetal scalp electrode showed a close agreement; the root mean square error between all corresponding averaged NI-FECG and fetal scalp electrode beats was 13.6 ms, which is lower than the lowest adult root mean square error of 16.1 ms observed in related adult QT studies. These results provide evidence that NI-FECG technology enables accurate extraction of the fetal QT interval.
- Published
- 2016