1. [The enzymatic linkage of fibrinogenesis and fibrinolysis (author's transl)].
- Author
-
Zimmermann RE and Lubinus J
- Subjects
- Aminocaproates pharmacology, Animals, Avian Sarcoma Viruses, Cell Transformation, Neoplastic, Dexamethasone pharmacology, Factor XII, Fibrinolysin biosynthesis, Humans, L Cells drug effects, Lysine pharmacology, Mice, Peptide Hydrolases metabolism, Plasminogen metabolism, Plasminogen Activators, Receptors, Cell Surface, Simian virus 40, Streptokinase metabolism, Tranexamic Acid pharmacology, Urokinase-Type Plasminogen Activator metabolism, Fibrin biosynthesis, Fibrinolysis, Hemostasis
- Abstract
The coagulation cascade can be triggered by an extrinsic or intrinsic signal. The response is a highly complex activation sequence of several serine proteases. This physiological event of hemostasis comprises the activation of the kinin system as well as other plasma constituents. As an expression of the dynamic balance between fibrinogenesis and fibrinolysis plasminogen is activated either by proteases deriving from the blood clotting cascade or by its linkage to the kallikrein kinin system. Inhibitors of the fibrinolytic events have to be directed specifically against serine proteases or they may be used to interact with the substrate fibrin thus its degradation is delayed.
- Published
- 1978
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