1. Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry
- Author
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Carles, García-Cervera, Vicente, Giner-Galvañ, Philip, Wikman-Jorgensen, Jaime, Laureiro, Manuel, Rubio-Rivas, Anthony, Gurjian Arena, Francisco, Arnalich-Fernandez, José Luis, Beato Pérez, Juan Antonio, Vargas Núñez, Jesús Javier, González Igual, Jesús, Díez-Manglano, Manuel, Méndez Bailón, María José, García Blanco, Santiago J, Freire Castro, Judit, Aranda Lobo, Luis, Manzano, Jeffrey Oskar, Magallanes Gamboa, Luis, Arribas Pérez, Julio, González Moraleja, Ruth, Calderón Hernaiz, Javier, García Alegría, Amara, González Noya, Ricardo, Gómez Huelgas, Carlos, Lumbreras Bermejo, and Juan Miguel, Antón Santos
- Subjects
Fibrin Fibrinogen Degradation Products ,Hospitalization ,Venous Thrombosis ,SARS-CoV-2 ,COVID-19 ,Humans ,Registries ,Venous Thromboembolism ,Letter to the Editor ,Retrospective Studies - Abstract
Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities.To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19.Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19.Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation93% (45.4% vs. 33.1%; p = 0.0003), higher at admission pDd (median [IQR]: 1.4 [0.6-5.5] vs. 0.6 [0.4-1.2] μg/ml; p0.0001) and platelet count (median [IQR]: 208 [158-289] vs. 189 [148-245] platelets × 10In hospitalized patients with COVID-19, a pDd value greater than 3.0 μg/ml can be considered to screen VTE and to consider full-dose anticoagulation.
- Published
- 2021