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Your search keyword '"Zhengjia Zeng"' showing total 3 results
Start Over Author "Zhengjia Zeng" Topic flame retardants
3 results on '"Zhengjia Zeng"'

1. Review of the environmental occurrence, analytical techniques, degradation and toxicity of TBBPA and its derivatives.

Author

Sunday OE, Bin H, Guanghua M, Yao C, Zhengjia Z, Xian Q, Xiangyang W, and Weiwei F

Subjects
Adult, Dust analysis, Humans, Environmental Pollutants analysis, Environmental Pollutants toxicity, Flame Retardants analysis, Flame Retardants toxicity, Polybrominated Biphenyls analysis, Polybrominated Biphenyls toxicity
Abstract

BFRs (brominated flame retardants) are a class of compounds that are added to or applied to polymeric materials to avoid or reduce the spread of fire. Tetrabromobisphenol A (TBBPA) is one of the known BFR used many in industries today. Due to its wide application as an additive flame retardant in commodities, TBBPA has become a common indoor contaminant. Recent researches have raised concerns about the possible hazardous effect of exposure to TBBPA and its derivatives in humans and wildlife. This review gives a thorough assessment of the literature on TBBPA and its derivatives, as well as environmental levels and human exposure. Several analytical techniques/methods have been developed for sensitive and accurate analysis of TBBPA and its derivatives in different compartments. These chemicals have been detected in practically every environmental compartment globally, making them a ubiquitous pollutant. TBBPA may be subject to adsorption, biological degradation or photolysis, photolysis after being released into the environment. Treatment of TBBPA-containing waste, as well as manufacturing and usage regulations, can limit the release of these chemicals to the environment and the health hazards associated with its exposure. Several methods have been successfully employed for the treatment of TBBPA including but not limited to adsorption, ozonation, oxidation and anaerobic degradation. Previous studies have shown that TBBPA and its derivative cause a lot of toxic effects. Diet and dust ingestion and have been identified as the main routes of TBBPA exposure in the general population, according to human exposure studies. Toddlers are more vulnerable than adults to be exposed to indoor dust through inadvertent ingestion. Furthermore, TBBP-A exposure can occur during pregnancy and through breast milk. This review will go a long way in closing up the knowledge gap on the silent and over ignored deadly effects of TBBPA and its derivatives and their attendant consequences., (Copyright © 2021 Elsevier Inc. All rights reserved.) more...

Published
2022
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2. Transcriptomic sequencing reveals the potential molecular mechanism by which Tetrabromobisphenol A bis (2-hydroxyethyl ether) exposure exerts developmental neurotoxicity in developing zebrafish (Danio rerio)

Author

Emmanuel Sunday Okeke, Xian Qian, Junhao Che, Guanghua Mao, Yao Chen, Hai Xu, Yangyang Ding, Zhengjia Zeng, Xiangyang Wu, and Weiwei Feng

Subjects
Polymers, Physiology, Health, Toxicology and Mutagenesis, Polybrominated Biphenyls, Thyrotropin, Cell Biology, General Medicine, Toxicology, Ether, Biochemistry, Animals, Cytokines, Dimethyl Sulfoxide, RNA, Messenger, Transcriptome, Water Pollutants, Chemical, Zebrafish, Ethers, Flame Retardants
Abstract

Tetrabromobisphenol A bis (2-hydroxyethyl ether) (TBBPA-DHEE) is a derivative of Tetrabromobisphenol A (TBBPA) used as an intermediate flame retardant in engineering polymers. The mechanism of neurodevelopmental toxicity of TBBPA-DHEE remains unclear due to limited toxicological data. We performed behavioral and transcriptomic analyses to assess the neurodevelopmental effects of TBBPA-DHEE on developing zebrafish and potential toxicity mechanisms. Our result shows that exposure to TBBPA-DHEE significantly increased mortality, deformity rate, and reduction in hatch rate, hatchability, and body length relative to the DMSO control. The behavior analysis indicates that TBBPA-DHEE significantly reduced the spontaneous movement of larva compared to the control. The TSH and GH levels were significantly reduced in all the exposure groups in a concentration-dependent manner relative to the DMSO control. TBBPA-DHEE exhibited a significant reduction in locomotor activity across all the exposure groups in the light/dark locomotion test. The transcriptomic analysis result shows that 579 genes were differentially expressed. KEGG analysis shows the enrichment of complement cascade, JAK-STAT signaling pathway, cytokine-cytokine interaction, and phototransduction pathway resulting in a change in mRNA expression of their genes. These observed changes in developmental endpoints, hormonal level, and alteration in mRNA expression of component genes involved in neurodevelopmental pathways could be part of the possible mechanism of the observed toxic effects of TBBPA-DHEE exposure on zebrafish. This study could reveal the possible neurodevelopmental toxicity of TBBPA-DHEE to aquatic species, which could help uncover the health implications of emerging environmental contaminants. more...

Published
2022
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3. Transcriptomic profiling and differential analysis revealed the neurodevelopmental toxicity mechanisms of zebrafish (Danio rerio) larvae in response to tetrabromobisphenol A bis(2–hydroxyethyl) ether (TBBPA-DHEE) exposure

Author

Emmanuel Sunday Okeke, Mengna Luo, Weiwei Feng, Yiran Zhang, Guanghua Mao, Yao Chen, Zhengjia Zeng, Xian Qian, Lei Sun, Liuqing Yang, and Xiangyang Wu

Subjects
Physiology, Health, Toxicology and Mutagenesis, Polybrominated Biphenyls, Cell Biology, General Medicine, Toxicology, Ether, Biochemistry, Rats, Larva, Animals, Transcriptome, Zebrafish, Ethers, Flame Retardants
Abstract

Tetrabromobisphenol A bis(2-hydroxyetyl) ether (TBBPA-DHEE) is among the main derivatives of Tetrabromobisphenol A (TBBPA). Result from previous study showed that TBBPA-DHEE can cause neurotoxicity in rat. In this study, zebrafish larvae were used for evaluation of TBBPA-DHEE-induced developmental toxicity, apoptosis, oxidative stress and the potential molecular mechanisms of action. Our result showed that TBBPA-DHEE exposure caused a significant concentration-dependent developmental toxicity endpoints like death rate, malformation rate, growth rate. TBBPA-DHEE altered locomotor and enzymes activities of larvae and caused apoptosis within the brain indicating the potential TBBPA-DHEE-induced cardiac, brain impairment in the zebrafish larvae. Our transcriptomic analysis shows that 691 genes were differentially expressed (DEGs) (539 upregulated, 152 downregulated). The KEGG and GO enrichment pathway analysis shows that the DEGs were involved in development, immunity, enzyme activity. Our study provides novel evidence on the neurodevelopmental toxicity and toxicity mechanism of TBBPA-DHEE which are vital for assessment of the environmental toxicity and risk assessment of the chemical. more...

Published
2022
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