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Your search keyword '"Chen, Hong‐Xuan"' showing total 2 results
Start Over Author "Chen, Hong‐Xuan" Topic flavonoids
2 results on '"Chen, Hong‐Xuan"'

1. The studies of anti-inflammatory and analgesic activities and pharmacokinetics of Oxytropis falcate Bunge extraction after transdermal administration in rats.

Author

Chen ZP, Qu MM, Chen HX, Liu D, Xiao YY, Chen J, Lu TL, and Cai BC

Subjects
Acetic Acid, Analgesics pharmacology, Animals, Anti-Inflammatory Agents pharmacology, Behavior, Animal drug effects, Biological Availability, Chalcones pharmacokinetics, Dose-Response Relationship, Drug, Edema chemically induced, Edema drug therapy, Female, Flavonoids pharmacology, Flavonoids therapeutic use, Hot Temperature, Inflammation blood, Inflammation drug therapy, Joint Diseases blood, Joint Diseases drug therapy, Male, Mice, Mice, Inbred Strains, Pain blood, Pain drug therapy, Plant Extracts pharmacology, Rats, Rats, Wistar, Xylenes, Analgesics therapeutic use, Anti-Inflammatory Agents therapeutic use, Flavonoids pharmacokinetics, Oxytropis chemistry, Phytotherapy, Plant Extracts pharmacokinetics, Plant Extracts therapeutic use
Abstract

The aim of this study was to evaluate the activities of anti-inflammatory and analgesic of the total flavonoids extraction from Oxytropis falcate Bunge (FEO) after transdermal administration. The pharmacokinetics and absolute bioavailability of FEO in rat, furthermore, was studied. Firstly, the anti-inflammatory and analgesic effects of the FEO were studied by xylene-induced ear edema, adjuvant-induced joint inflammation law in rats, acetic acid-induced writhing and hot-plate tests in mice. Secondly, we developed a sensitive and specific HPLC method to analyze 2', 4'-dihydroxychalcone (TFC, the mainly ingredient of FEO) in rat plasma to study the pharmacokinetic of TEC. The results showed FEO has anti-inflammatory and analgesic property in a dose-dependent manner, and that the high dose group (90.6 mg/kg) of FEO appeared more significantly effective than the positive drug. From the pharmacokinetic studies of TFC in rats, we got the main pharmacokinetic parameters of TFC, providing a basis for the future studies in clinic., (Copyright © 2010 Elsevier B.V. All rights reserved.)

Published
2011
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2. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats

Author

Chen, Zhi-peng, Sun, Jun, Chen, Hong-xuan, Xiao, Yan-yu, Liu, Dan, Chen, Jun, Cai, Hao, and Cai, Bao-chang

Subjects
*GINKGO, *MEDICINAL plants, *PHARMACOKINETICS, *LABORATORY rats, *BIOAVAILABILITY, *PHOSPHOLIPIDS, *BIOCHEMISTRY, *ALTERNATIVE medicine, *ANALYSIS of variance, *ANIMAL experimentation, *BIOPHYSICS, *PHYSICAL & theoretical chemistry, *COMPARATIVE studies, *COMPUTER software, *DOSAGE forms of drugs, *FLAVONOIDS, *MATHEMATICS, *RESEARCH methodology, *ORAL drug administration, *QUERCETIN, *RATS, *REGRESSION analysis, *X-rays, *PLANT extracts, *DATA analysis
Abstract

Abstract: The aim of this study was to improve the oral bioavailability of Ginkgo biloba extract (GBE) through preparing G. biloba extract phospholipid complexes (GBP) and G. biloba extract solid dispersions (GBS). Firstly we prepared the GBP and GBS and studied their physicochemical properties by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and dissolution. Then we studied the pharmacokinetic characteristics and bioavailability in rats. The results showed that the bioavailability of quercetin, kaempferol and isorhamnetin in rats was increased remarkably after oral administration of GBP and GBS comparing with GBE. The bioavailabilities of GBP increased more than that of GBS. [Copyright &y& Elsevier]

Published
2010
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