1. Bioactive flavonoid dimers from Chinese dragon's blood, the red resin of Dracaena cochinchinensis.
- Author
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Lang GZ, Li CJ, Gaohu TY, Li C, Ma J, Yang JZ, Zhou TT, Yuan YH, Ye F, Wei JH, and Zhang DM
- Subjects
- Animals, Crystallography, X-Ray, Dimerization, Enzyme Inhibitors chemistry, Flavonoids chemistry, Humans, Models, Molecular, Neuroprotective Agents chemistry, PC12 Cells, Plant Extracts chemistry, Protein Tyrosine Phosphatase, Non-Receptor Type 1 metabolism, Rats, Dracaena chemistry, Enzyme Inhibitors pharmacology, Flavonoids pharmacology, Neuroprotective Agents pharmacology, Plant Extracts pharmacology, Protein Tyrosine Phosphatase, Non-Receptor Type 1 antagonists & inhibitors
- Abstract
Seven flavonoid dimers, biflavocochins A-G, together with six known compounds were isolated from the red resins of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1-7 was assigned by experimental and quantum chemical calculated ECD spectra, and that of 4 was further established by X-ray diffraction analysis using Cu Kα radiation. Compounds 1-3 are novel dimers of homoisoflavonoid and dihydrochalcone with a unique dibenzopyran ring. Compounds 2, 6, 7 exhibited moderate PTP1B inhibitory activities in an enzyme assay. Compound 1 showed neuroprotective effect on serum deficiency-induced cellular damage in PC12 cells., Competing Interests: Declaration of Competing Interest The authors declared that there is no conflict of interest., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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