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2 results on '"Weng, Weihong"'

1. Protective effects of baicalin and octreotide on intestinal mucosa of rats with severe acute pancreatitis.

Author

Zhang X, Feng G, Weng W, Liang J, Lin N, Cai Y, Xu R, Zhou N, Yuan M, Yuan W, and Xia X

Subjects
Animals, Apoptosis drug effects, Disease Models, Animal, Ileum drug effects, Ileum pathology, Intestinal Mucosa drug effects, Intestinal Mucosa pathology, Male, NF-kappa B blood, Pancreatitis, Acute Necrotizing blood, Pancreatitis, Acute Necrotizing mortality, Pancreatitis, Acute Necrotizing pathology, Rats, Rats, Sprague-Dawley, Severity of Illness Index, Survival Rate, Treatment Outcome, Tumor Necrosis Factor-alpha blood, bcl-2-Associated X Protein blood, Anti-Infective Agents administration & dosage, Flavonoids administration & dosage, Gastrointestinal Agents administration & dosage, Octreotide administration & dosage, Pancreatitis, Acute Necrotizing drug therapy
Abstract

Background/aims: To compare the protective effects of baicalin and octreotide on intestinal mucosa of rats with severe acute pancreatitis and to explore the application value of baicalin as a new drug., Methods: Severe acute pancreatitis rats were randomly divided into a model control group, baicalin-treated group and octreotide-treated group. An equal number of normal rats were included in a sham-operated group. At 3, 6 and 12 hours (h) after operation, mortality rate, pathological changes in the intestinal mucosa of the terminal ileum, expression levels of nuclear factor (NF)-kappaB, Bax and Bcl-2 proteins, and apoptosis indices in the rats in each group were evaluated. Endotoxin and tumor necrosis factor (TNF)-alpha contents in blood were also determined., Results: At 12h after operation, the survival rates in both the baicalin-treated group and octreotide-treated group were higher than in the model control group, and the difference was significant (p<0.05). At all time points after the operation, endotoxin and TNF-alpha values as well as the expression levels of NF-kappaB protein and pathological severity scores in the intestinal mucosa in the two treated groups were, to varying degrees, significantly lower than those in the model control group (p<0.05, p<0.01 and p<0.001, respectively). Moreover, the expression level of Bax protein at 3h postoperatively as well as the expression level of Bax protein and apoptosis indices at 6h postoperatively in the two treated groups were significantly higher than those in the model control group (p<0.01)., Conclusions: Baicalin and octreotide exert significant protective effects on severe acute pancreatitis-induced intestinal mucosa injury via a mechanism that is associated with inhibiting inflammatory mediators and inducing apoptosis. In comparison with the pharmacological action of octreotide, we believe that baicalin, as a new drug, has similar protective effects on the intestinal mucosa of severe acute pancreatitis rats, and therefore deserves further study and development.

Published
2009

2. Baicalin Protects Thymus of Rats with Severe Acute Pancreatitis

Author

Yuan Meijuan, Yang Qijun, Zhu Wei, Xu Rujun, Weng Weihong, Wang Qing, Fang Lini, He Jinxian, Zhang Xiping, Ye Jing, and Feng Guanghua

Subjects
Male, medicine.medical_specialty, P-selectin, Immunology, Octreotide, Apoptosis, Thymus Gland, Severity of Illness Index, Rats, Sprague-Dawley, chemistry.chemical_compound, Gastrointestinal Agents, Internal medicine, medicine, Animals, Immunology and Allergy, Medicine, Chinese Traditional, Pathological, bcl-2-Associated X Protein, Flavonoids, Model control, Staining and Labeling, Caspase 3, business.industry, Anti-Inflammatory Agents, Non-Steroidal, NF-kappa B, Epithelial Cells, medicine.disease, Rheumatology, Rats, Disease Models, Animal, P-Selectin, Endocrinology, Pancreatitis, Proto-Oncogene Proteins c-bcl-2, chemistry, Acute Disease, Acute pancreatitis, business, Baicalin, medicine.drug
Abstract

To study the protective role of Baicalin on rats thymus with severe acute pancreatitis (SAP). The SAP rats were randomly assigned to the model control, Baicalin treated and Octreotide treated groups. Normal rats were assigned to the sham-operated group. The rat survival rates, pathological changes of thymus, apoptotic indexes and expression levels of NF-kappaB, Bax, Bcl-2, Caspase-3 and P-selectin of all groups were observed and recorded at 3, 6 and 12 h after operation, respectively. Rat survival rates were significantly higher in both Baicalin- and Octreotide-treated groups than those in the model control group at 12 h (P0.05). The thymus pathological score was significantly lower in Baicalin treated group than in control group at 3 and 12 h (P0.05). The expression of NF-kappaB, Bax and Bcl-2 in thymus tissue was negative in all groups. At 3 h after operation, the staining intensity, positive staining rate and intensity of Caspase-3 protein in the thymuses of the Baicalin treated group were significantly higher than those in the model control group (P0.01). At different time points after operation, no marked difference was observed in the staining intensity of P-selectin protein between the Baicalin treated group and the model control group (P0.05). At 6 h after operation, the positive staining rate and intensity of P-selectin protein in the Baicalin treated group was significantly lower than those in the model control group (P0.05). The apoptotic indexes were significantly higher in treated group than in model control group at 6 h (P0.05). Baicalin has a protective role on the thymus of SAP rats, and its effect of decreasing inflammatory mediators level in blood, inhibiting P-selectin expression and inducing apoptosis of thymocytes may involve in the mechanism of its protective role.

Published
2009

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