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Introduction: Detachment of denture teeth from denture base is one of the most common reasons for costly denture repairs .This study aimed at evaluating the bond strength of an acrylic denture tooth to polyamide injection-molded thermoplastic denture base material compared with three conventional polymethylmethacrylate (PMMA) denture base resins. Materials and Method: A total of 40 acrylic denture molar teeth were randomly allocated into four groups (n=10) of heat-polymerized (HP), Auto-polymerized (AP), Injection molded (IM) and Polyamide thermoplastic (PT). All denture base/acrylic teeth combinations underwent 5000 thermal cycles (5-55◦C).Samples were subjected to shear bond strength test by a universal testing machine with a 1 mm/min crosshead speed .Data were analyzed using ANOVA and Tukey’s tests(α=0.05). Results: Mean ±SD of shear bond strength values were (MPa) 4.82±1.21, 4.52±1.67, 3.7±0.84 and 4.13±2.21 for groups HP, AP, IM and PT respectively. No significant difference was found among the experimental groups (P=0.429). Conclusion: Polyamide thermoplastic denture base resin was similar to conventional PMMA denture base materials in terms of bond strength to artificial denture teeth.