1. ReactIRTM Flow Cell - A New Analytical Tool for Continuous Flow Chemical Processing
- Author
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Heiko Lange, Nigel L. Gaunt, Brian Wittkamp, Catherine F. Carter, Steven V. Ley, Ian R. Baxendale, Jon G. Goode, CARTER Catherine, F., Lange, Heiko, LEY Steven, V., BAXENDALE Ian, R., Wittkamp, Brian, GOODE Jon, G., GAUNT Nigel, L., CARTER Catherine, F, Lange, H, LEY Steven, V, BAXENDALE Ian, R, Wittkamp, B, GOODE Jon, G, and GAUNT Nigel, L
- Subjects
Materials science ,business.industry ,Continuous flow ,flow chemistry ,Organic Chemistry ,Reactive intermediate ,React IR ,Analytical chemistry ,Flow cell ,inline monitoring ,Flow chemistry ,Flow (mathematics) ,Reagent ,reaction control ,Analysis software ,Physical and Theoretical Chemistry ,Process engineering ,business ,Microscale chemistry - Abstract
A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.
- Published
- 2010